Evidence map›Paper›PMID 26491441›Full record

ReviewInternational journal of endocrinology2015

A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings.

Andrea Gogos, Alyssa M Sbisa, Jeehae Sun, Andrew Gibbons, Madhara Udawela, Brian Dean

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05282277 (Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis), which is not on this map. Cited by 92 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 3 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05282277 phase4recruitingnot on this mapstarted 2022, after this paper: background citation

Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2026Enrolled103ConditionsDepression, Psychosis, AnhedoniaArmsTransdermal Estradiol, Micronized Progesterone, Matching Placebo Patch, Raclopride C11
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 232 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrea GogosFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Alyssa M SbisaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia ; School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086, Australia.
Jeehae SunFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia ; School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086, Australia.
Andrew GibbonsFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Madhara UdawelaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Brian DeanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Florey Institute of Neuroscience and Mental Health · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness. In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia patients and review the clinical findings on the use of estradiol as an adjunctive treatment in schizophrenia patients. Preclinical research that has used animal models and molecular probes to investigate estradiol's underlying protective mechanisms is also substantially discussed, with particular focus on estradiol's impact on the major neurotransmitter systems implicated in schizophrenia, namely, the dopamine, serotonin, and glutamate systems.

Identifiers

PMID26491441
PMCPMC4600562
OpenAlexW1916212716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.