Evidence map›Paper›PMID 26491423›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society

LC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.

Dong-Hyun Kim, Fiona Achcar, Rainer Breitling, Karl E Burgess, Michael P Barrett

Open access · hybridAbstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery.Metabolomics : Official journal of the Metabolomic Society · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Metabolic characterisation ofRSC advances · 2020
    Article
  11. Metabolic characterisation of THP-1 macrophage polarisation using LC-MS-based metabolite profiling.Metabolomics : Official journal of the Metabolomic Society · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Polyamines in protozoan pathogens.The Journal of biological chemistry · 2018
    Review
  16. Article
  17. Ornithine uptake and the modulation of drug sensitivity inFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Dong-Hyun KimWellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA UK ; Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD UK.
Fiona AchcarWellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA UK.
Rainer BreitlingManchester Centre of Synthetic Biology for Fine and Speciality Chemicals, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester, M1 7DN UK.
Karl E BurgessGlasgow Polyomics, Wolfson Wohl Cancer Research Centre, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, G61 1QH UK.
Michael P BarrettWellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA UK ; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, G61 1QH UK.
University of Glasgow · GBWellcome Centre for Molecular Parasitology · GBUniversity of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/I004599/1Wellcome Trust 085349Wellcome Trust 104111
6 · The paper itself

Abstract

Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite,

Indexed as

13C-labelled E. coliAbsolute metabolite quantificationLC–MSMetabolic fluxTrypanosome

Identifiers

PMID26491423
PMCPMC4605981
OpenAlexW2156850933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.