Evidence map›Paper›PMID 26491307›Full record

ArticleInternational journal of nanomedicine2015

Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds.

Annapoorna Mohandas, Sudheesh Kumar P T, Biswas Raja, Vinoth-Kumar Lakshmanan, Rangasamy Jayakumar

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 143 citations in OpenAlex.

  1. Article
  2. Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026
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  14. Recent Advances in Antimicrobial Peptide Hydrogels.International journal of molecular sciences · 2023
    Review
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  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Annapoorna MohandasAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.
Sudheesh Kumar P TAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.
Biswas RajaAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.
Vinoth-Kumar LakshmananAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.
Rangasamy JayakumarAmrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.
Amrita Institute of Medical Sciences and Research Centre · INAmrita Vishwa Vidyapeetham · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alginate hydrogel/zinc oxide nanoparticles (nZnO) composite bandage was developed by freeze-dry method from the mixture of nZnO and alginate hydrogel. The developed composite bandage was porous with porosity at a range of 60%-70%. The swelling ratios of the bandages decreased with increasing concentrations of nZnO. The composite bandages with nZnO incorporation showed controlled degradation profile and faster blood clotting ability when compared to the KALTOSTAT® and control bandages without nZnO. The prepared composite bandages exhibited excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and methicillin resistant S. aureus (MRSA). Cytocompatibility evaluation of the prepared composite bandages done on human dermal fibroblast cells by Alamar assay and infiltration studies proved that the bandages have a non-toxic nature at lower concentrations of nZnO whereas slight reduction in viability was seen with increasing nZnO concentrations. The qualitative analysis of ex-vivo re-epithelialization on porcine skin revealed keratinocyte infiltration toward wound area for nZnO alginate bandages.

Indexed as

BandagesAlginatesAnti-Infective AgentsBlood CoagulationCell AdhesionCell SurvivalEpitheliumEscherichia coliFibroblastsGlucuronic AcidHemostasisHexuronic AcidsHumansHydrogel, Polyethylene Glycol DimethacrylateMembrane PotentialsMethicillin-Resistant Staphylococcus aureusAlginatesAnti-Infective AgentsGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateZinc Oxidealginateantimicrobial activityhemostatichydrogelwound healingZnO nanoparticle

Identifiers

PMID26491307
PMCPMC4599611
OpenAlexW1866823924

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.