Evidence map›Paper›PMID 26491294›Full record

ArticleInternational journal of nanomedicine2015

Anti-transferrin receptor-modified amphotericin B-loaded PLA-PEG nanoparticles cure Candidal meningitis and reduce drug toxicity.

Xiaolong Tang, Yong Liang, Yongqiang Zhu, Chunmei Xie, Aixia Yao, Li Chen, Qinglin Jiang, Tingting Liu, Xiaoyu Wang, Yunyun Qian and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Xiaolong TangClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China ; State Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Yong LiangClinical Laboratory, Huai'an Hospital Affiliated of Xuzhou Medical College, Huaian, People's Republic of China.
Yongqiang ZhuClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China ; Department of Medical Genetics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Chunmei XieSchool of Biotechnology, Southern Medical University, Guangzhou, People's Republic of China.
Aixia YaoClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Li ChenClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Qinglin JiangClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Tingting LiuClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Xiaoyu WangClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Yunyun QianClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Jia WeiClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Wenxuan NiClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Jingjing DaiClinical Laboratory, Huainan First People's Hospital and First Affiliated Hospital of Medical College, Anhui University of Science & Technology, Huainan, People's Republic of China.
Zhenyou JiangDepartment of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou, People's Republic of China ; Guangdong Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, People's Republic of China.
Wei HouState Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Anhui University of Science and Technology · CNHuazhong University of Science and Technology · CNJinan University · CNSouthern Medical University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatal fungal infections in central nervous system (CNS) can occur through hematogenous spread or direct extension. At present, hydrophobic amphotericin B (AMB) is the most effective antifungal drug in clinical trials. However, AMB is hydrophobic and therefore penetrates poorly into the CNS, and therapeutic levels of AMB are hard to achieve. The transferrin receptor (TfR/CD71) located at the blood-brain barrier mediates transferrin transcytosis. In order to enhance the receptor-mediated delivery of AMB into CNS with therapeutic level, an anti-TfR antibody (OX26)-modified AMB-loaded PLA (poly[lactic acid])-PEG (polyethylene glycol)-based micellar drug delivery system was constructed. The prepared OX26-modified AMB-loaded nanoparticles (OX26-AMB-NPs) showed significant reduction of CNS fungal burden and an increase of mouse survival time. In conclusion, OX26-AMB-NPs represent a promising novel drug delivery system for intracerebral fungal infection.

Indexed as

Drug Delivery SystemsAmphotericin BAnimalsAntibodies, MonoclonalAntifungal AgentsCandida glabrataCandidiasisDrug-Related Side Effects and Adverse ReactionsErythrocytesMeningitisMiceMice, Inbred BALB CMicellesNanoparticlesPolyethylene GlycolsRabbitsAmphotericin BAntibodies, MonoclonalAntifungal AgentsMicellesmonomethoxypolyethyleneglycol-polylactide block copolymerPolyethylene GlycolsReceptors, TransferrinTransferrinamphotericin Bblood–brain barrierdrug deliverynanocarriertransferrin receptor

Identifiers

PMID26491294
PMCPMC4599718
OpenAlexW1869894172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.