ArticleJournal of clinical microbiology2016
Molecular Characterization of Nonhemolytic and Nonpigmented Group B Streptococci Responsible for Human Invasive Infections.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03371056 (Innovative Strategies for Perinatal Infectious Risk Reduction), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Strategies for Perinatal Infectious Risk Reduction
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Improved detection of group BMicrobiology spectrum · 2026Article
- Analysis of serotype distribution and characteristics of nonhemolytic and nonpigmented strains among group B Streptococcus isolates in a southern Taiwan local hospital.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Comparative Analysis of the Molecular Characteristics of Group BAnnals of laboratory medicine · 2023Article
- Streptococcus-related acute suppurative thyroiditis in a COVID-19-positive child: A rare case report.Clinical case reports · 2023Article
- Virulence, phenotype and genotype characteristics of invasive group B Streptococcus isolates obtained from Swedish pregnant women and neonates.Annals of clinical microbiology and antimicrobials · 2022Article
- An Application of Real-Time PCR and CDC Protocol May Significantly Reduce the Incidence ofPathogens (Basel, Switzerland) · 2022Article
- A Retrospective National Study on Colonization Rate and Antimicrobial Susceptibility ofYonsei medical journal · 2022Article
- Feed Insects as a Reservoir of Granadaene-Producing Lactococci.Frontiers in microbiology · 2022Article
- Antimicrobial resistance in colonizing group B Streptococcus among pregnant women from a hospital in Vietnam.Scientific reports · 2021Article
- Bacterial toxins in musculoskeletal infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Development and analytical validation of real-time PCR for the detection of Streptococcus agalactiae in pregnant women.BMC pregnancy and childbirth · 2020Article
- Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.Journal of innate immunity · 2020Article
- Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates.PloS one · 2019Article
- Genomic Insights Into the Distribution and Evolution of Group B Streptococcus.Frontiers in microbiology · 2019Review
- A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection.Nature communications · 2018Article
- Development of a melting-curve based multiplex real-time PCR assay for simultaneous detection of Streptococcus agalactiae and genes encoding resistance to macrolides and lincosamides.BMC pregnancy and childbirth · 2018Article
- Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus.PLoS genetics · 2018Article
- A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence.The Journal of infectious diseases · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group B Streptococcus (GBS) is a common commensal bacterium in adults, but is also the leading cause of invasive bacterial infections in neonates in developed countries. The β-hemolysin/cytolysin (β-h/c), which is always associated with the production of an orange-to-red pigment, is a major virulence factor that is also used for GBS diagnosis. A collection of 1,776 independent clinical GBS strains isolated in France between 2006 and 2013 was evaluated on specific medium for β-h/c activity and pigment production. The genomic sequences of nonhemolytic and nonpigmented (NH/NP) strains were analyzed to identify the molecular basis of this phenotype. Gene deletions or complementations were carried out to confirm the genotype-phenotype association. Sixty-three GBS strains (3.5%) were NH/NP, and 47 of these (74.6%) originated from invasive infections, including bacteremia and meningitis, in neonates or adults. The mutations are localized predominantly in the cyl operon, encoding the β-h/c pigment biosynthetic pathway and, in the abx1 gene, encoding a CovSR regulator partner. In conclusion, although usually associated with GBS virulence, β-h/c pigment production is not absolutely required to cause human invasive infections. Caution should therefore be taken in the use of hemolysis and pigmentation as criteria for GBS diagnosis in routine clinical laboratory settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.