Evidence map›Paper›PMID 26491150›Full record

ArticleJournal of virology2016

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene.

Hye-Ra Lee, Jaba Mitra, Stacy Lee, Shou-Jiang Gao, Tae-Kwang Oh, Myung Hee Kim, Taekjip Ha, Jae U Jung

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Circular DNA tumor viruses make circular RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. Plant MicroRNAs in Cross-Kingdom Regulation of Gene Expression.International journal of molecular sciences · 2018
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hye-Ra LeeDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA hyelee@usc.edu jaeujung@med.usc.edu.
Jaba MitraDepartment of Physics, Center for the Physics of Living Cells and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Stacy LeeDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Shou-Jiang GaoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Tae-Kwang OhInfection and Immunity Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Myung Hee KimInfection and Immunity Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Taekjip HaDepartment of Physics, Center for the Physics of Living Cells and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jae U JungDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA hyelee@usc.edu jaeujung@med.usc.edu.
University of Southern California · USKorea Research Institute of Bioscience and Biotechnology · KRUniversity of Illinois Urbana-Champaign · US

Funding

Roles of the K3 and K5 in KSHV Persistence and PathogenesisP01CA180779 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2017
$7.3M
Molecular Basis of KSHV PathogenesisR01CA082057 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 1999 to 2016
$5.1M
MOLECULAR BASIS FOR HERPESVIRUS SAIMIRI ONCOGENICITYR01CA031363 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 1985 to 2014
$4.9M
Role of viral BCI-2 mediated anti-apoptosis and-autophagyR01AI073099 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2007 to 2017
$4.3M
KSHV Epigenetic RegulationR01DE023926 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2024
$4.2M
Single Molecule Study of Helicase MechanismsR01GM065367 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HA, TAEKJIP · 2002 to 2014
$3.6M
KSHV RTA: more than viral replicationR01CA115284 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2005 to 2015
$3.1M
TRIM9-mediated anti-viral immune pathwayR01AI116585 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OU, J.-H. JAMES · 2015 to 2019
$2.3M
When Autophagy Meets PhagocytosisR01HL110609 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2011 to 2015
$2.0M
Howard Hughes Medical InstituteNCI NIH HHS CA115284NCI NIH HHS CA180779NCI NIH HHS CA31363NCI NIH HHS CA82057NCI NIH HHS P01 CA180779NCI NIH HHS R01 CA031363NCI NIH HHS R01 CA082057NCI NIH HHS R01 CA115284NHLBI NIH HHS HL110609NHLBI NIH HHS R01 HL110609NIAID NIH HHS AI073099NIAID NIH HHS AI116585NIAID NIH HHS R01 AI073099NIAID NIH HHS R01 AI116585NIDCR NIH HHS DE023926NIDCR NIH HHS R01 DE023926NIGMS NIH HHS R01 GM065367
6 · The paper itself

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication. This shows that KSHV vIRF4 suppresses host G1-S transition, possibly providing an intracellular milieu favorable for its replication.

Indexed as

Cell Cycle CheckpointsGenes, bcl-1Host-Pathogen Interactionsbeta CateninDown-RegulationHerpesvirus 8, HumanInterferon Regulatory FactorsPeptide FragmentsSialoglycoproteinsViral ProteinsVirus Replicationbeta Cateninbone sialoprotein (35-62), humanCTNNB1 protein, humanInterferon Regulatory FactorsPeptide FragmentsSialoglycoproteinsviral interferon regulatory factorsViral Proteins

Identifiers

PMID26491150
PMCPMC4702683
OpenAlexW2280614170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.