Evidence map›Paper›PMID 26491094›Full record

Trial reportJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2015

Novel Use of Ultrasound Elastography to Quantify Muscle Tissue Changes After Dry Needling of Myofascial Trigger Points in Patients With Chronic Myofascial Pain.

Diego Turo, Paul Otto, Murad Hossain, Tadesse Gebreab, Katherine Armstrong, William F Rosenberger, Hui Shao, Jay P Shah, Lynn H Gerber, Siddhartha Sikdar

5 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03323567 early_phase1completednot on this mapstarted 2016, after this paper: background citation

A Comparison of Collagen, Lidocaine and Saline Intramuscular Injections, in Myofascial Pain Patients With Trigger Points in Masseter Muscle.

TypeinterventionalSponsorMedical University of SilesiaRan2016 to 2017Enrolled43ConditionsTemporomandibular DisorderArmsMD Muscle GUNA collagen, Lidocaine 2% Injectable Solution, Saline Solution, Hypertonic
NCT04045457 nacompletednot on this map

A Study to Determine the Tissue Properties, Vascular Physiology and Biochemical Milieu of Myofascial Trigger Points

TypeinterventionalSponsorGeorge Mason UniversityRan2010 to 2016Enrolled85ConditionsMyofascial PainArmsdry needling
NCT04578626 nacompletednot on this mapstarted 2020, after this paper: background citation

Morphological Changes in Asymptomatic Perimandibular Muscles After Dry Needling Assessed With Rehabilitative Ultrasound Imaging

TypeinterventionalSponsorPoliambulatorio Physio PowerRan2020 to 2020Enrolled17ConditionsAsymptomatic State, Temporomandibular Joint, Masticatory MusclesArmsdry needling
NCT06060925 completednot on this mapstarted 2023, after this paper: background citation

Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain

TypeobservationalSponsorGeorge Mason UniversityRan2023 to 2025Enrolled96ConditionsMyofascial Pain Syndrome, HealthyArmsUltrasound imaging, Bioimpedance spectroscopy, Electromyography, Physical examination
NCT06603168 nacompletednot on this mapstarted 2023, after this paper: background citation

Autonomic Recalibration Approach to Myofascial Pain Elimination

TypeinterventionalSponsorEdward Via Virginia College of Osteopathic MedicineRan2023 to 2024Enrolled20ConditionsChronic Pain (Back / Neck), Autonomic DysregulationArmsAutonomic Recalibration Treatment
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Assessment of Myofascial Trigger Points via Imaging: A Systematic Review.American journal of physical medicine & rehabilitation · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Diego TuroDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Paul OttoDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Murad HossainDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Tadesse GebreabDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Katherine ArmstrongDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
William F RosenbergerDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Hui ShaoDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Jay P ShahDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Lynn H GerberDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.).
Siddhartha SikdarDepartments of Bioengineering (D.T., T.G., S.S.), Electrical and Computer Engineering (P.O., M.H.), and Statistics (W.F.R., H.S.) and Center for the Study of Chronic Illness and Disability (K.A., L.H.G.), George Mason University, Fairfax, Virginia USA; and Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, Maryland USA (J.P.S.). ssikdar@gmu.edu.
George Mason University · USNational Institutes of Health · US

Funding

Pathogenesis and Pathophysiological Mechanisms of Myofascial Trigger PointsR01AR057348 · NIAMS · GEORGE MASON UNIVERSITY · PI SIKDAR, SIDDHARTHA · 2010 to 2013
$1.8M
STATISTICAL METHODOLOGY FOR CANCER CLINICAL TRIALSR01CA087746 · NCI · UNIVERSITY OF MARYLAND BALT CO CAMPUS · PI ROSENBERGER, WILLIAM F. · 2000 to 2004
$631k
NCI NIH HHS R01 CA087746NIAMS NIH HHS 1R01-AR057348NIAMS NIH HHS R01 AR057348
6 · The paper itself

Abstract

objectivesTo compare a mechanical heterogeneity index derived from ultrasound vibration elastography with physical findings before and after dry-needling treatment of spontaneously painful active myofascial trigger points in the upper trapezius muscle.

methodsForty-eight patients with chronic myofascial pain enrolled in a prospective interventional trial of 3 weekly dry-needling treatments for active myofascial trigger points. Trigger points were evaluated at baseline and at treatment completion using palpation, the pressure-pain threshold, and the mechanical heterogeneity index. Thirty patients were reevaluated at 8 weeks. Trigger points that "responded" changed to tissue that was no longer spontaneously painful, with or without the presence of a palpable nodule. Trigger points that "resolved" changed to tissue without a palpable nodule. The mechanical heterogeneity index was defined as the proportion of the upper trapezius muscle that appeared mechanically stiffer on elastography. Statistical significance for comparisons was determined at P < .05.

resultsFollowing 3 dry needle treatments, the mechanical heterogeneity index decreased significantly for the 38 myofascial trigger points (79% of 48) that responded to treatment. Among these, the baseline mechanical heterogeneity index was significantly lower for the 13 trigger points (27% of 38) that resolved, but the decrease after 3 dry needle treatments did not reach significance. The pressure-pain threshold improved significantly for both groups. At 8 weeks, the mechanical heterogeneity index decreased significantly for the 22 trigger points (73% of 30) that responded and for the 10 (45% of 22) that resolved. The pressure-pain threshold improvement was significant for trigger points that responded but did not reach significance for resolved trigger points.

conclusionsThe mechanical heterogeneity index identifies changes in muscle tissue properties that correlate with changes in the myofascial trigger point status after dry needling.

Indexed as

Acupuncture TherapyAdultChronic PainElasticity Imaging TechniquesElastic ModulusFacial PainFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMuscle, SkeletalReproducibility of ResultsSensitivity and SpecificityStress, MechanicalTreatment Outcomedry needlingmusculoskeletal ultrasoundmyofascial pain syndromemyofascial trigger pointsultrasound elastography

Identifiers

PMID26491094
PMCPMC5555767
OpenAlexW2178777158

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.