ArticleCerebral cortex (New York, N.Y. : 1991)2016
Maturation of Sensori-Motor Functional Responses in the Preterm Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Encoding of mechanical nociception differs in the adult and infant brain.Scientific reports · 2016Trial
- Global remapping of the sensory homunculus emerges early in childhood development.Nature communications · 2026Article
- Neural encoding of auditory rhythm beyond cortical auditory areas before the age of term.iScience · 2025Article
- 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.bioRxiv : the preprint server for biology · 2025Article
- The FinnBrain multimodal neonatal template and atlas collection.Communications biology · 2025Article
- Early Development and Co-Evolution of Microstructural and Functional Brain Connectomes: A Multi-Modal MRI Study in Preterm and Full-Term Infants.Human brain mapping · 2025Article
- Typical and disrupted small-world architecture and regional communication in full-term and preterm infants.PNAS nexus · 2025Article
- Co-developing sleep-wake and sensory foundations for cognition in the human fetus and newborn.Developmental cognitive neuroscience · 2025Review
- Brain age prediction and deviations from normative trajectories in the neonatal connectome.Nature communications · 2024Article
- Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment.Nature communications · 2024Article
- Functional neuroimaging of responses to multiple sensory stimulations in newborns with perinatal asphyxia.Translational pediatrics · 2023Article
- Structural and functional asymmetry of the neonatal cerebral cortex.Nature human behaviour · 2023Article
- Your turn, my turn. Neural synchrony in mother-infant proto-conversation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- The role of early functional neuroimaging in predicting neurodevelopmental outcomes in neonatal encephalopathy.European journal of pediatrics · 2023Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- The developing brain structural and functional connectome fingerprint.Developmental cognitive neuroscience · 2022Article
- Development of functional organization within the sensorimotor network across the perinatal period.Human brain mapping · 2022Article
- Article
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8 authors.
Funding
Abstract
Preterm birth engenders an increased risk of conditions like cerebral palsy and therefore this time may be crucial for the brain's developing sensori-motor system. However, little is known about how cortical sensori-motor function matures at this time, whether development is influenced by experience, and about its role in spontaneous motor behavior. We aimed to systematically characterize spatial and temporal maturation of sensori-motor functional brain activity across this period using functional MRI and a custom-made robotic stimulation device. We studied 57 infants aged from 30 + 2 to 43 + 2 weeks postmenstrual age. Following both induced and spontaneous right wrist movements, we saw consistent positive blood oxygen level-dependent functional responses in the contralateral (left) primary somatosensory and motor cortices. In addition, we saw a maturational trend toward faster, higher amplitude, and more spatially dispersed functional responses; and increasing integration of the ipsilateral hemisphere and sensori-motor associative areas. We also found that interhemispheric functional connectivity was significantly related to ex-utero exposure, suggesting the influence of experience-dependent mechanisms. At term equivalent age, we saw a decrease in both response amplitude and interhemispheric functional connectivity, and an increase in spatial specificity, culminating in the establishment of a sensori-motor functional response similar to that seen in adults.
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