ArticleJournal of cell science2015
Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.
Article in Journal of cell science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Proliferation and differentiation in intestinal organoids are balanced by ligand-modulated EGFR trafficking.Life science alliance · 2026Article
- Human tissue-resident CD8 T cells contribute to trophoblast homeostasis in health and during acute inflammation.bioRxiv : the preprint server for biology · 2026Article
- Gastric intestinal metaplasia: unraveling the multifactorial pathogenesis and advancing risk stratification for gastric cancer prevention.Cellular and molecular life sciences : CMLS · 2026Review
- The human placenta and its role in reproductive outcomes revisited.Physiological reviews · 2025Review
- Traction force and mechanosensitivity mediate species-specific implantation patterns in human and mouse embryos.Science advances · 2025Article
- Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes.Cell & bioscience · 2025Article
- Marmoset and human trophoblast stem cells differ in signaling requirements and recapitulate divergent modes of trophoblast invasion.Cell stem cell · 2024Article
- Establishment and comparison of human term placenta-derived trophoblast cells†.Biology of reproduction · 2024Article
- Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids.Nature communications · 2023Article
- Article
- The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation.Development (Cambridge, England) · 2023Article
- Application of a JEG-3 organoid model to study HLA-G function in the trophoblast.Frontiers in immunology · 2023Article
- Accessing the human trophoblast stem cell state from pluripotent and somatic cells.Cellular and molecular life sciences : CMLS · 2022Review
- Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- WNT and NOTCH signaling in human trophoblast development and differentiation.Cellular and molecular life sciences : CMLS · 2022Review
- Primary Trophoblast Cultures: Characterization of HLA Profiles and Immune Cell Interactions.Frontiers in immunology · 2022Article
- Aberrant epithelial polarity cues drive the development of precancerous airway lesions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Unique features and emerging in vitro models of human placental development.Reproductive medicine and biology · 2020Review
- Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta.Nature protocols · 2020Article
- Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia.The American journal of pathology · 2019Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During placentation, foetal trophoblasts invade deeply into maternal tissue to establish a foeto-maternal circulation. We have previously shown that extravillous trophoblast (EVT) lineage cells express ErbB2 and ErbB3, of which the potential as an oncogenic unit is well established. However, a physiological function of this receptor combination in humans remains a puzzling question. Here, we demonstrate neuregulin 1 (NRG1) expression and secretion by human decidual stromal cells. Stimulation of human primary trophoblasts with exogenous NRG1 induced phosphorylation of ErbB2, ErbB3 and related downstream effectors. Co-immunoprecipitation experiments confirmed the formation of ErbB2-ErbB3 dimers upon ligand engagement. Along this line, receptor knockdown and ErbB3 neutralization strongly diminished NRG1-dependent activation of the signalling complex. Functional studies revealed that NRG1 promotes EVT formation in placental explant cultures. Although, in the presence of NRG1, basal and camptothecin-induced trophoblast apoptosis was significantly repressed, this effect was abolished upon ErbB3 inhibition. Notably, camptothecin provoked a strong reduction of trophoblast cell column size, whereas NRG1-treated explants were refractory to the compound. Taken together, our findings newly identify a physiological function of the NRG1-ErbB2-ErbB3 axis in trophoblast survival during human placental development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.