ArticleBone & joint research2015
Glucocorticoids inhibit shaft fracture healing but not metaphyseal bone regeneration under stable mechanical conditions.
Article in Bone & joint research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Therapeutic Efficacy of Modified Cocktail Analgesia After Minimally Invasive Chevron Osteotomy for Hallux Valgus: A Retrospective Case Series Study.Local and regional anesthesia · 2026Article
- Perioperative dexamethasone: Effects on length of stay, perioperative outcomes, and safety in isolated lower extremity long bone fracture fixation.Journal of clinical orthopaedics and trauma · 2025Article
- Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats.International journal of molecular sciences · 2024Article
- Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD.NPJ systems biology and applications · 2023Article
- Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.Endocrine reviews · 2022Review
- Article
- Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice.Biomedicines · 2022Article
- Site-Specific Fracture Healing: Comparison between Diaphysis and Metaphysis in the Mouse Long Bone.International journal of molecular sciences · 2021Review
- Distinct Glucocorticoid Receptor Actions in Bone Homeostasis and Bone Diseases.Frontiers in endocrinology · 2021Review
- Patient-dependent factors for fractures union failure among Riyadh population 2016.Journal of family medicine and primary care · 2020Article
- Mesenchymal stem cell-macrophage crosstalk and bone healing.Biomaterials · 2019Review
- A Jack of All Trades: Impact of Glucocorticoids on Cellular Cross-Talk in Osteoimmunology.Frontiers in immunology · 2019Review
- Abaloparatide versus teriparatide: a head to head comparison of effects on fracture healing in mouse models.Acta orthopaedica · 2018Article
- Different composition of leucocytes in cortical and cancellous bone healing in a mouse model.Bone & joint research · 2018Article
- Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture.Journal of molecular endocrinology · 2018Review
- Decisive differences in the bone repair processes of the metaphysis and diaphysis in young mice.Bone reports · 2018Article
- A systematic review of current osteoporotic metaphyseal fracture animal models.Bone & joint research · 2018Article
- The forgotten phase of fracture healing: The need to predict nonunion.Bone & joint research · 2017Article
- Systemic corticosteroids improve tendon healing when given after the early inflammatory phase.Scientific reports · 2017Article
- Isolated metaphyseal injury influences unrelated bones.Acta orthopaedica · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHealing in cancellous metaphyseal bone might be different from midshaft fracture healing due to different access to mesenchymal stem cells, and because metaphyseal bone often heals without a cartilaginous phase. Inflammation plays an important role in the healing of a shaft fracture, but if metaphyseal injury is different, it is important to clarify if the role of inflammation is also different. The biology of fracture healing is also influenced by the degree of mechanical stability. It is unclear if inflammation interacts with stability-related factors.
methodsWe investigated the role of inflammation in three different models: a metaphyseal screw pull-out, a shaft fracture with unstable nailing (IM-nail) and a stable external fixation (ExFix) model. For each, half of the animals received dexamethasone to reduce inflammation, and half received control injections. Mechanical and morphometric evaluation was used.
resultsAs expected, dexamethasone had a strong inhibitory effect on the healing of unstable, but also stable, shaft fractures. In contrast, dexamethasone tended to increase the mechanical strength of metaphyseal bone regenerated under stable conditions.
conclusionsIt seems that dexamethasone has different effects on metaphyseal and diaphyseal bone healing. This could be explained by the different role of inflammation at different sites of injury. Cite this article: Bone Joint Res 2015;4:170-175.
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Registered trials
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