ArticleInflammation2016
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.
Article in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- From cats to cortex:Frontiers in psychiatry · 2026Review
- Toxoplasma gondii as a drug for anti-tumor immunotherapy: mechanisms, challenges, and perspectives.Parasite (Paris, France) · 2026Review
- Review
- Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review.Journal of neuroinflammation · 2024Review
- Antinociceptive and anti-inflammatory activities of the methanol extract ofArchives of Razi Institute · 2024Article
- Pathological mechanisms of glial cell activation and neurodegenerative and neuropsychiatric disorders caused byFrontiers in microbiology · 2024Review
- Curcumin ameliorates chronicIranian journal of basic medical sciences · 2023Article
- Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation.Parasitology research · 2022Article
- The High Potency of Green Synthesized Copper Nanoparticles to Prevent the Toxoplasma gondii Infection in Mice.Acta parasitologica · 2021Article
- Green synthesis of zinc nanoparticles usingSaudi journal of biological sciences · 2021Article
- Article
- Morphological and biochemical repercussions ofBrain, behavior, & immunity - health · 2021Article
- Effect of chitosan onParasite epidemiology and control · 2020Review
- Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?Journal of neuroinflammation · 2020Review
- Prophylactic effects of biogenic selenium nanoparticles on acute toxoplasmosis: An in vivo study.Annals of medicine and surgery (2012) · 2020Article
- Downregulation of lncRNA-11496 in the Brain Contributes to Microglia ApoptosisFrontiers in molecular neuroscience · 2020Article
- Article
- Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats.Galen medical journal · 2019Article
- Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition.Journal of neuroinflammation · 2018Article
- The association of latent toxoplasmosis and level of serum testosterone in humans.BMC research notes · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that in Toxoplasma gondii infection, communication among immune cells promotes neuroinflammation through cytokine networks and induces pain sensitivity under conditions of neuropathic pain. The animal model of Toxoplasma infection was established by the intraperitoneal inoculation of 20-25 tissue cysts from Tehran strain of T. gondii to BALB/c mice. Amitriptyline (20 mg/kg, i.p., 1/day) administrated to animals for 7 days before behavioral tests. Pain behavioral tests including tail flick, hot plate, and formalin test were evaluated in all the groups. The mRNA levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were examined by real-time PCR. Results revealed that T. gondii induce hyperalgesia in the infected mice, whereas amitriptyline showed a promising effect against the hyperalgesia induced by Toxoplasma infection. The mRNA levels of the aforementioned cytokines significantly (P < 0.05) increased in the infected mice compared to the uninfected ones. Obtained findings suggested that T. gondii infection could promote neuroinflammation through cytokine networks and induced hyperalgesia in BALB/c mice, whereas amitriptyline as an analgesic drug reverses them.
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