Evidence map›Paper›PMID 26490955›Full record

ArticleInternational journal of geriatric psychiatry2016

Course of cognitive impairment following attempted suicide in older adults.

Swathi Gujral, Semhar Ogbagaber, Alexandre Y Dombrovski, Meryl A Butters, Jordan F Karp, Katalin Szanto

Abstract read
In one paragraph

Article in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Search for solutions, learning, simulation, and choice processes in suicidal behavior.Wiley interdisciplinary reviews. Cognitive science · 2022
    Review
  5. Late-Onset Suicide: A Dementia Prodrome?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  6. Problem-Solving Therapy Effects on Suicidal Ideation: The Role of Reduction in Functional Disability.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  7. Article
  8. Article
  9. Predictors of serious suicidal behavior in late-life depression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020
    Article
  10. Neurocognition and the Suicidal Process.Current topics in behavioral neurosciences · 2020
    Article
  11. Article
  12. Article
  13. Suicidal Thoughts and Behaviors Among First-Year College Students: Results From the WMH-ICS Project.Journal of the American Academy of Child and Adolescent Psychiatry · 2018
    Article
  14. Treatment Emergent Suicidal Ideation in depressed older adults.International journal of geriatric psychiatry · 2017
    Article
  15. Cognitive Deficits: Underappreciated Contributors to Suicide.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Swathi GujralDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Semhar OgbagaberDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Alexandre Y DombrovskiCenter for Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA, USA.
Meryl A ButtersDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Jordan F KarpWestern Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Katalin SzantoWestern Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Short Term Variability in Affect and Rest Activity Rhythms in Long Term Chronic and Highly Variable Suicidal Ideation in Depressed Older AdultsR01MH085651 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANGA CSILLA GALFALVY, Swathi Gujral · 2010 to 2026
$9.6M
University of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7M
Reward Learning in Late-Life Suicidal BehaviorR01MH100095 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Alexandre Y. Dombrovski · 2014 to 2026
$6.8M
Optimizing Care for Older Adults with Back Pain and DepressionR01AG033575 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KARP, JORDAN F · 2010 to 2014
$2.3M
Cognitive and Affective Neuroscience of Decision-Making in Late-Life SuicideK23MH086620 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOMBROVSKI, ALEXANDRE Y. · 2009 to 2013
$853k
NCATS NIH HHS KL2 TR000146NCATS NIH HHS UL1 TR000005NIA NIH HHS AG033575NIA NIH HHS R01 AG033575NIMH NIH HHS K23 MH086620NIMH NIH HHS R01 MH05436NIMH NIH HHS R01 MH085651NIMH NIH HHS R01MH08-5651-03NIMH NIH HHS R01MH085651-05NIMH NIH HHS R01 MH100095
6 · The paper itself

Abstract

objectiveCognitive impairment has been associated with late-life suicidal behavior. Without longitudinal data it is unclear whether these are transient features of a depressive state or stable impairments. We examined longitudinally the course of cognitive impairment in older adults with depression and a history of suicide attempt.

methodsWe investigated the persistence of cognitive impairment over time in 198 depressed older adults (age >60); 91 suicide attempters, 39 depressed individuals with suicidal ideation (ideators), and 68 non-suicidal depressed adults assessed over a 2-year period at four time points. We used linear mixed effects modeling to examine group differences in trajectories of cognitive decline over 2 years, using the Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale (DRS), and Executive Interview (EXIT).

resultsOver the 2-year period, suicide attempters performed significantly worse than both suicide ideators and non-suicidal depressed older adults on the MMSE (mean difference: from ideators: -0.88, p = 0.02; from non-suicidal depressed: -1.52, p < 0.01), while on the EXIT and DRS, suicide attempters performed significantly worse than non-suicidal depressed older adults (mean difference: in EXIT: -1.75, p = 0.01; in DRS: 3.04, p < 0.01; in MMSE: 1.15, p < 0.01). Cognitive impairment in suicide attempters partly resolved, as indicated by a group × time interaction on the DRS (p = 0.039), but not the EXIT (p = 0.58) or the MMSE (p = 0.08).

conclusionsCognitive impairment in late-life suicidal behavior appears to involve both a stable and a state-related component.

Indexed as

AgedAged, 80 and overCognitionCognition DisordersDepressive DisorderExecutive FunctionFemaleHumansLinear ModelsMaleMiddle AgedPsychiatric Status Rating ScalesSuicidal IdeationSuicide, Attemptedcognitivedepressionexecutive functionolder adultssuicide

Identifiers

PMID26490955
PMCPMC4840049

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.