ArticleEnvironmental science and pollution research international2016
Diazinon, an organophosphate pesticide, induces oxidative stress and genotoxicity in cells deriving from large intestine.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Protective Effect of Barberry (Berberis vulgaris L.) Extract on Oxidative Stress and Behavioral Changes in Toxicity Induced by Diazinon in the Brain Tissue of Male Rats.Brain and behavior · 2026Article
- Protocatechuic acid mitigates diazinon-induced lung injury in rats through modulation of oxidative stress, inflammatory, Keap-1/Nrf-2/HO-1 and ER stress-mediated apoptotic pathways.Iranian journal of basic medical sciences · 2026Article
- Resveratrol mitigates diazinon-induced neurotoxicity during fetal brain development.Iranian journal of basic medical sciences · 2026Article
- Impact of pesticide diazinon on gastric cancer cell lines and the alteration of cholinergic and serotonergic pathway genes affecting cell proliferation.Scientific reports · 2025Article
- Toxicological assessment of omethoate insecticide in Allium cepa L.Scientific reports · 2025Article
- Diazinon induces testicular dysfunction and testicular cell damage through increased reactive oxygen species production in mouse.Cell death discovery · 2025Article
- Article
- n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats.Toxicological research · 2024Article
- Article
- Potential protective effects of chrysin against immunotoxicity induced by diazinon.Scientific reports · 2022Article
- Diazinon reduction in food products: a comprehensive review of conventional and emerging processing methods.Environmental science and pollution research international · 2022Review
- Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma.Biomedicines · 2022Article
- Effects of Insecticides and Microbiological Contaminants onMolecules (Basel, Switzerland) · 2021Review
- Combined Exposure to Diazinon and Nicotine Exerts a Synergistic Adverse Effect In Vitro and Disrupts Brain Development and Behaviors In Vivo.International journal of molecular sciences · 2021Article
- Comparative immuno-modulatory effects of basil and sesame seed oils against diazinon-induced toxicity in rats; a focus on TNF-α immunolocalization.Environmental science and pollution research international · 2021Article
- Electromagnetic Fields Modify Redox Balance in the Rat Gastrointestinal Tract.Frontiers in public health · 2021Article
- Comparative Evaluation of the Cytotoxicity of Glyphosate-Based Herbicides and Glycine in L929 and Caco2 Cells.Frontiers in public health · 2021Article
- Metabolism of insecticide diazinon byRSC advances · 2020Article
- Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon.Journal of biomedical physics & engineering · 2020Article
- Toxicity Evaluation of the Subacute Diazinon in Aged Male Rats: Hematological Aspects.Cardiovascular & hematological disorders drug targets · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diazinon (DZ) (O,O-diethyl-O-[2-isopropyl-6-methyl-4-pyrimidinyl]phosphorothioate) is an organophosphate pesticide which is extensively used to control household insects and fruit and vegetable crops. The exposure to this pesticide has been linked to the development of the serious problem in several experimental animals. The contamination of food by DZ may increase its danger to humans. The aim of this study was to investigate the toxic effect of DZ on intestine using an in vitro model (HCT116). Therefore, we evaluated the cell viability, elucidated the generation of free radicals, measured the mitochondrial membrane potential, and valued DNA fragmentation. Our results showed that DZ is cytotoxic to HCT116. It causes oxidative damage through the generation of free radicals and induces lipid peroxidation and DNA fragmentation. We also demonstrated that such effects can be responsible for DZ-induced apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.