Observational studySurgical endoscopy2016
Neonatal brain oxygenation during thoracoscopic correction of esophageal atresia.
Observational study in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507295 (the Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
the Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates (RCT)
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Thoracoscopic versus conventional thoracotomy for esophageal atresia/tracheoesophageal fistula repair: a comprehensive meta-analysis of 25 comparative studies.Pediatric surgery international · 2025Pooled it
- Neurodevelopmental outcome of patients with congenital gastrointestinal malformations: a systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2021Pooled it
- Thoracoscopic repair of esophageal atresia.Surgery today · 2020Pooled it
- Thoracoscopy vs. thoracotomy for the repair of esophageal atresia and tracheoesophageal fistula: a systematic review and meta-analysis.Pediatric surgery international · 2019Pooled it
- Acid-Base Status and Cerebral Oxygenation in Neonates: A Systematic Qualitative Review of the Literature.Children (Basel, Switzerland) · 2025Review
- Neurodevelopmental Outcomes in Newborns with Congenital Gastrointestinal Atresias.Children (Basel, Switzerland) · 2025Article
- Respiratory Support Strategies for Surgical Neonates: A Review.Children (Basel, Switzerland) · 2025Review
- Article
- Near-infrared spectroscopy for perioperative assessment and neonatal interventions.Pediatric research · 2024Review
- Minimal Access in Pediatric Surgery: An Overview on Progress towards Dedicated Instrument Developments and Anesthesiologic Advances to Enhance Safe Completion of Procedures.Children (Basel, Switzerland) · 2024Article
- Primary repair of esophageal atresia Gross type CWorld journal of gastrointestinal surgery · 2024Article
- Application of different COFrontiers in pediatrics · 2024Article
- Effect of different mechanical ventilation modes on cerebral blood flow during thoracoscopic surgery in neonates: A randomised controlled trial.Indian journal of anaesthesia · 2022Article
- Considerations of single-lung ventilation in neonatal thoracoscopic surgery with cardiac arrest caused by bilateral pneumothorax: A case report.World journal of clinical cases · 2022Article
- [Near-infrared spectroscopy : Technique, development, current use and perspectives].Der Anaesthesist · 2021Review
- Thoracoscopic resection of congenital pulmonary airway malformations: timing and technical aspects.Journal of thoracic disease · 2020Article
- Clinical analysis of surgery for type III esophageal atresia via thoracoscopy: a study of a Chinese single-center experience.Journal of cardiothoracic surgery · 2020Article
- Pediatric Laparoscopy and Adaptive Oxygenation and Hemodynamic Changes.Pediatric reports · 2017Article
- Brain Oxygenation During Thoracoscopic Repair of Long Gap Esophageal Atresia.World journal of surgery · 2017Article
- Monitoring Cerebral Oxygenation in Neonates: An Update.Frontiers in pediatrics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the effects of carbon dioxide (CO2) insufflation on cerebral oxygenation during thoracoscopy in neonates. Near-infrared spectroscopy can measure perioperative brain oxygenation [regional cerebral oxygen saturation (rScO2)].
aimsTo evaluate the effects of CO2 insufflation on rScO2 during thoracoscopic esophageal atresia (EA) repair.
methodsThis is an observational study during thoracoscopic EA repair with 5 mmHg CO2 insufflation pressure. Mean arterial blood pressure (MABP), arterial oxygen saturation (SaO2), partial pressure of arterial carbon dioxide (paCO2), pH, and rScO2 were monitored in 15 neonates at seven time points: baseline (T0), after anesthesia induction (T1), after CO2-insufflation (T2), before CO2-exsufflation (T3), and postoperatively at 6 (T4), 12 (T5), and 24 h (T6).
resultsMABP remained stable. SaO2 decreased from T0 to T2 [97 ± 3-90 ± 6 % (p < 0.01)]. PaCO2 increased from T0 to T2 [41 ± 6-54 ± 15 mmHg (p < 0.01)]. pH decreased from T0 to T2 [7.33 ± 0.04-7.25 ± 0.11 (p < 0.05)]. All parameters recovered during the surgical course. Mean rScO2 was significantly higher at T1 compared to T2 [77 ± 10-73 ± 7 % (p < 0.05)]. Mean rScO2 levels never dropped below a safety threshold of 55 %.
conclusionThe impact of neonatal thoracoscopic repair of EA with insufflation of CO2 at 5 mmHg was studied. Intrathoracic CO2 insufflation caused a reversible decrease in SaO2 and pH and an increase in paCO2. The rScO2 was higher at anesthesia induction but remained stable and within normal limits during and after the CO2 pneumothorax, which suggest no hampering of cerebral oxygenation by the thoracoscopic intervention. Future studies will focus on the long-term effects of this surgery on the developing brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.