Evidence map›Paper›PMID 26490707›Full record

SynthesisNature communications2015

The transcriptional landscape of age in human peripheral blood.

Marjolein J Peters, Roby Joehanes, Luke C Pilling, Claudia Schurmann, Karen N Conneely, Joseph Powell, Eva Reinmaa, George L Sutphin, Alexandra Zhernakova, Katharina Schramm and 106 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 451 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
451citing papers in PubMed, 4 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

451 citing papers in PubMed, 4 syntheses or guidelines pooled it, 739 citations in OpenAlex.

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391 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

116 authors at 20 institutions in 11 countries.

Marjolein J PetersDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Roby JoehanesThe National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Luke C PillingEpidemiology and Public Health, University of Exeter Medical School, Exeter EX4 1DB, UK.
Claudia SchurmannDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany.
Karen N ConneelyDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia 30301, USA.
Joseph PowellCentre for Neurogenetics and Statistical Genomics, Queensland Brain Institute, University of Queensland, St Lucia, Brisbane, Queensland 4000, Australia.
Eva ReinmaaEstonian Genome Center, University of Tartu, Tartu 0794, Estonia.
George L SutphinNathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Alexandra ZhernakovaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen 9700RB, The Netherlands.
Katharina SchrammInstitute of Human Genetics, Helmholz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Yana A WilsonNeuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia.
Sayuko KobesPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85001, USA.
Taru TukiainenInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00131, Finland.
NABEC/UKBEC Consortium
Yolande F RamosDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
Harald H H GöringDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA.
Myriam FornageDivision of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Sciences, Center at Houston, Texas 77001, USA.
Yongmei LiuDepartment of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Sina A GharibComputational Medicine Core, Center for Lung Biology, University of Washington, Seattle, Washington 98101, USA.
Barbara E StrangerSection of Genetic Medicine, Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60290, USA.
Philip L De JagerProgram in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02108, USA.
Abraham AvivCenter of Human Development and Aging, New Jersey Medical School, Newark 07101, USA.
Daniel LevyThe National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Joanne M MurabitoThe National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Peter J MunsonThe Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20817, USA.
Tianxiao HuanThe National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam 3000CA, The Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Jeroen van RooijDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Lisette StolkDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Linda BroerDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Michael M P J VerbiestDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Mila JhamaiDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Pascal ArpDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 0794, Estonia.
Liina TserelMolecular Pathology, Institute of Biomedicine, University of Tartu, Tartu 0794, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu 0794, Estonia.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1, UK.
Pärt PetersonMolecular Pathology, Institute of Biomedicine, University of Tartu, Tartu 0794, Estonia.
Silva KaselaInstitute of Molecular and Cell Biology, Estonian Genome Center, University of Tartu, Tartu 0794, Estonia.
Veryan CoddDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE1, UK.
Annette PetersInstitute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Cavin K Ward-CavinessInstitute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Christian HerderInstitute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40593, Germany.
Melanie WaldenbergerInstitute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Michael RodenInstitute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40593, Germany.
Paula SingmannInstitute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Sonja ZeilingerInstitute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Thomas IlligHannover Unified Biobank, Hannover Medical School, Hannover 30519, Germany.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany.
Hans-Jörgen GrabeDepartment of Psychiatry and Psychotherapy, Helios Hospital Stralsund, University Medicine Greifswald, Greifswald 17489, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald 17489, Germany.
Leif SteilDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany.
Thomas KocherUnit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald 17489, Germany.
Anna MurrayEpidemiology and Public Health, University of Exeter Medical School, Exeter EX4 1DB, UK.
David MelzerEpidemiology and Public Health, University of Exeter Medical School, Exeter EX4 1DB, UK.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria di Firenze, Florence 50123, Italy.
Eric K MosesCentre for Genetic Origins of Health and Disease, The University of Western Australia, and Faculty of Health Sciences, Curtin University, Perth, Western Australia 9011, Australia.
Jack W KentDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA.
Joanne E CurranDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA.
Matthew P JohnsonDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA.
Sarah Williams-BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA.
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen 9700RB, The Netherlands.
Allan F McRaeThe Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4000, Australia.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan 48103, USA.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan 48103, USA.
Iiris HovattaDepartment of Biosciences, University of Helsinki, Helsinki 00100, Finland.
Markus PerolaEstonian Genome Center, University of Tartu, Tartu 0794, Estonia.
Samuli RipattiInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00131, Finland.
Veikko SalomaaDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00131, Finland.
Anjali K HendersThe Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4000, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4000, Australia.
Alicia K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30301, USA.
Divya MehtaMax-Planck Institute of Psychiatry, Munich 80331, Germany.
Elisabeth B BinderMax-Planck Institute of Psychiatry, Munich 80331, Germany.
K Maria NylocksDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30301, USA.
Elizabeth M KennedyDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia 30301, USA.
Torsten KlengelMax-Planck Institute of Psychiatry, Munich 80331, Germany.
Jingzhong DingDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA.
Astrid M Suchy-DiceyDepartment of Epidemiology, University of Washington, Seattle, Washington 98101, USA.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington, Seattle, Washington 98101, USA.
Jennifer BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90501, USA.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90501, USA.
Jeanine Houwing-DuistermaatDepartment of Medical Statistics, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
Margreet KloppenburgDepartment of Rheumatology, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
Quinta HelmerDepartment of Medical Statistics, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
Wouter den HollanderDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
Shannon BeanNathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Towfique RajDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02138, USA.
Noman BakhshiNeuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia.
Qiao Ping WangNeuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia.
Lisa J OystonNeuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Russell P TracyDepartment of Pathology, University of Vermont College of Medicine, Colchester, Vermont 98195, USA.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4000, Australia.
Stephen T TurnerDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA.
Ingrid MeulenbeltDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands.
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30301, USA.
Jian YangThe Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4000, Australia.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen 9700RB, The Netherlands.
Johannes KettunenInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00131, Finland.
Peter M VisscherThe Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4000, Australia.
G Gregory NeelyNeuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia.
Ron KorstanjeNathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85001, USA.
Holger ProkischInstitute of Human Genetics, Helmholz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Luigi FerrucciClinical Research Branch, National Institute on Aging, Baltimore, Maryland 21218, USA.
Tonu EskoEstonian Genome Center, University of Tartu, Tartu 0794, Estonia.
Alexander TeumerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands.
Andrew D JohnsonThe National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Erasmus University Rotterdam · NLLeiden University Medical Center · NLNational Institutes of Health · USUniversitätsmedizin Greifswald · DEHelmholtz Zentrum München · DENational Institute on Aging · USTexas Biomedical Research Institute · USUniversity of Tartu · EEEmory University · USThe University of Queensland · AUUniversity of Washington · USUniversity College London · GBUniversity of Exeter · GBErasmus MC · NLFinnish Institute for Health and Welfare · FIGarvan Institute of Medical Research · AUJackson Laboratory · USMax Planck Institute of Psychiatry · DEFramingham Heart Study · USHarbor–UCLA Medical Center · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Molecular Profiling of Diabetes and its ComplicationsZIADK075071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANSON, ROBERT · 2012 to 2025
$7.4M
Statistical And Computational Methods For Gene Expression and Proteomic AnalysisZIACT000266 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI MUNSON, PETER J · 2009 to 2016
$4.2M
Genetic Determinants of Human Transcriptional AgingR01AG031277 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI WILLIAMS-BLANGERO, SARAH A. · 2008 to 2012
$2.7M
Exceptional Aging Across the Life Span: Framingham StudyR01AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MURABITO, JOANNE M · 2008 to 2011
$1.3M
NCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL105756NIA NIH HHS R01 AG029451NIA NIH HHS R01 AG031277NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.

Indexed as

TranscriptomeAgingBiomarkersDNA MethylationGene Expression ProfilingHumansWhite PeopleBiomarkers

Identifiers

PMID26490707
PMCPMC4639797
OpenAlexW2173367702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.