ArticleBMC complementary and alternative medicine2015
Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Mechanistic insights into the anti-benign prostatic hyperplasia effect of dihydromyricetin via suppression of the 5-AR/TGF-β1/Smad2 axis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The combination of water extracts ofNutrition research and practice · 2025Article
- Effect of Proanthocyanidins from Grape Seed Extract on Benign Prostatic Hyperplasia.Nutrients · 2024Article
- A cross-sectional quality assessment of TikTok content on benign prostatic hyperplasia.World journal of urology · 2023Article
- Efficacy of 1-Year CavacurminJournal of clinical medicine · 2023Article
- Inhibitory effects ofIranian journal of basic medical sciences · 2023Article
- Article
- Evaluation of the Therapeutic Effect of the Traditional Herbal MedicineAdvances in urology · 2022Article
- Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats.BMC complementary medicine and therapies · 2021Article
- Curcumin attenuates prostatic hyperplasia caused by inflammationPharmaceutical biology · 2021Article
- Effects of larval extracts from identifiedFood science & nutrition · 2021Article
- In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy.3 Biotech · 2021Article
- Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study.Translational andrology and urology · 2021Article
- Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia.Antioxidants (Basel, Switzerland) · 2021Article
- Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways.Inflammopharmacology · 2020Article
- Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review.Frontiers in pharmacology · 2020Review
- In Vivo Effects of Polymerized Anthocyanin from Grape Skin on Benign Prostatic Hyperplasia.Nutrients · 2019Article
- 6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis.BMB reports · 2019Article
- Kangquan Recipe Regulates the Expression of BAMBI Protein via the TGF-Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats.International neurourology journal · 2018Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBenign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress the development of BPH in male Wistar rats.
methodsSeven weeks male Wistar rats were and divided into 4 groups (normal group, BPH group, finasteride group, curcumin group; n = 8 for each group). In order to induce BPH in rats, rats were castrated and testosterone was injected subcutaneously everyday (s.c., 20 mg/kg). Rats in the curcumin group were treated 50 mg/kg, administered orally for 4 weeks. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed.
resultsCompared to the finasteride group as positive group, the curcumin group showed similarly protective effect on BPH in histopathologic morphology, prostate volume. Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ß1, and IGF1 were also decreased in the curcumin group.
conclusionsThese results suggested that curcumin inhibited the development of BPH and might a useful herbal treatment or functional food for BPH.
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