ArticleBiology open2015
Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity.
Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Signaling pathways in Drosophila testis niche: Local signals that regulate stem cell fate.Insect science · 2026Review
- Transcriptional regulation in cardiovascular aging.Frontiers in cardiovascular medicine · 2026Review
- Modulating DNA Polα Enhances Cell Reprogramming Across Species.bioRxiv : the preprint server for biology · 2024Article
- The Drosophila histone methyltransferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation.Development (Cambridge, England) · 2024Article
- Computational simulation of JAK/STAT signaling in somatic versus germline stem cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- ThebioRxiv : the preprint server for biology · 2024Article
- Canonical and non-canonical functions of STAT in germline stem cell maintenance.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- A single N-terminal amino acid determines the distinct roles of histones H3 and H3.3 in the Drosophila male germline stem cell lineage.PLoS biology · 2023Article
- Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.Nature communications · 2022Article
- Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage.Developmental cell · 2022Article
- Germline sex determination regulates sex-specific signaling between germline stem cells and their niche.Cell reports · 2022Article
- dRTEL1 is essential for the maintenance of Drosophila male germline stem cells.PLoS genetics · 2021Article
- Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.Developmental biology · 2021Review
- The histone demethylase KDM5 controls developmental timing inDevelopment (Cambridge, England) · 2019Article
- Asymmetric Centromeres Differentially Coordinate with Mitotic Machinery to Ensure Biased Sister Chromatid Segregation in Germline Stem Cells.Cell stem cell · 2019Article
- Review
- JAK/STAT signaling in stem cells and regeneration: fromDevelopment (Cambridge, England) · 2019Review
- Enhancer of polycomb maintains germline activity and genome integrity in Drosophila testis.Cell death and differentiation · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights fromJournal of experimental neuroscience · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Signaling pathways and epigenetic mechanisms have both been shown to play essential roles in regulating stem cell activity. While the role of either mechanism in this regulation is well established in multiple stem cell lineages, how the two mechanisms interact to regulate stem cell activity is not as well understood. Here we report that in the Drosophila testis, an H3K4me3-specific histone demethylase encoded by little imaginal discs (lid) maintains germline stem cell (GSC) mitotic index and prevents GSC premature differentiation. Lid is required in germ cells for proper expression of the Stat92E transcription factor, the downstream effector of the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling pathway. Our findings support a germ cell autonomous role for the JAK-STAT pathway in maintaining GSCs and place Lid as an upstream regulator of this pathway. Our study provides new insights into the biological functions of a histone demethylase in vivo and sheds light on the interaction between epigenetic mechanisms and signaling pathways in regulating stem cell activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.