ArticleMolecular immunology2015
Cell-autonomous requirement for TCF1 and LEF1 in the development of Natural Killer T cells.
Article in Molecular immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- β-Catenin stabilization protects against alveolar hemorrhage through amphiregulin- and BATF-mediated Tregs.JCI insight · 2026Article
- PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells.Frontiers in immunology · 2025Article
- Single-cell transcriptomics reveal different maturation stages and sublineage commitment of human thymic invariant natural killer T cells.Journal of leukocyte biology · 2024Article
- LEF1 enhances β-catenin transactivation through IDR-dependent liquid-liquid phase separation.Life science alliance · 2023Article
- TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.Cancer immunology, immunotherapy : CII · 2023Article
- TCF-1 negatively regulates the suppressive ability of canonical and noncanonical Tregs.Journal of leukocyte biology · 2023Article
- TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity.International journal of molecular sciences · 2023Article
- Pbrm1 intrinsically controls the development and effector differentiation of iNKT cells.Journal of cellular and molecular medicine · 2022Article
- Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity.Nature communications · 2022Article
- Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.Nature communications · 2021Article
- A divergent transcriptional landscape underpins the development and functional branching of MAIT cells.Science immunology · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.Frontiers in immunology · 2018Article
- How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.Frontiers in immunology · 2018Review
- The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.Scientific reports · 2017Article
- Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.American journal of cancer research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Natural killer T (NKT) cells develop from common CD4(+) CD8(+) thymocyte precursors. Transcriptional programs that regulate the development of NKT cells in the thymus development remain to be fully delineated. Here, we demonstrate a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of NKT cells. Conditional deletion of TCF1 alone results in a substantial reduction in NKT cells. The remaining NKT cells are eliminated when TCF1 and LEF1 are both deleted. These data reveal an essential role for TCF1 and LEF1 in development of NKT cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.