ArticleEuropean journal of pediatrics2016
Neuro-developmental outcome of a large cohort of growth discordant twins.
Article in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Twin differences in lateral ventricle size accompany twin differences in phonological decoding.Brain structure & function · 2025Article
- Association Between Maternal Subclinical Hypothyroidism and Growth Discordance in Twin Gestations: A Retrospective Study.International journal of women's health · 2025Article
- Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age.BMC public health · 2024Article
- Exposure to heavy metals and trace elements among pregnant women with twins: levels and association with twin growth discordance.Frontiers in public health · 2024Article
- Perinatal Outcomes and Neurodevelopment 1 Year after Birth in Discordant Twins According to Chorionicity.Medicina (Kaunas, Lithuania) · 2023Article
- Evidence for ethnicity and location as regulators of the newborn blood metabolome: a monozygous twin study.Frontiers in nutrition · 2023Article
- Physical growth and intelligence development of discordant dizygotic twins from birth to preschool age: a prospective cohort study.Italian journal of pediatrics · 2022Article
- Prediction of maternal complications and neonatal outcome in dichorionic diamniotic twins with fetal weight discordancy measured by ultrasonography.Scientific reports · 2022Article
- Neonatal and Long-Term Prognosis of Monochorionic Diamniotic Pregnancies Complicated by Selective Growth Restriction.Children (Basel, Switzerland) · 2022Article
- Developmental outcomes in small-for-gestational age twins using a singleton vs twin birthweight reference.American journal of obstetrics & gynecology MFM · 2021Article
- Predictive value of prenatal ultrasound parameters for dichorionic growth discordant twins.BMC pregnancy and childbirth · 2020Article
- Neurodevelopmental outcome of preterm twins at 5 years of age.Pediatric research · 2020Article
- The effect of placental location identified before delivery on birthweight discordance among diamniotic-dichorionic twin pregnancies: a three-year retrospective cohort study.Scientific reports · 2019Article
- The Impact of Selective Fetal Growth Restriction or Birth Weight Discordance on Long-Term Neurodevelopment in Monochorionic Twins: A Systematic Literature Review.Journal of clinical medicine · 2019Review
- Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins.The American journal of tropical medicine and hygiene · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOur aims were to study the effect of birthweight growth discordance (≥20%) on neuro-developmental outcome of monochorionic and dichorionic twins and to compare the relative effects of foetal growth discordance and prematurity on cognitive outcome. We performed a cross-sectional multicentre prospective follow-up study from a cohort of 948 twin pregnancies. One hundred nineteen birthweight-discordant twin pairs were examined (24 monochorionic pairs) and were matched for gestational age at delivery with 111 concordant control pairs. Participants were assessed with the Bayley Scales between 24 and 42 months of age. Analysis was by paired t test for intra-twin pair differences and by multiple linear regression. Compared to the larger twin of a discordant pair, the smaller twin performed significantly worse in cognition (mean composite cognitive score difference = -1.7, 95% confidence interval (CI) = 0.3-3.1, p = 0.01) and also in language and motor skills. Prematurity prior to 33 weeks' gestation, however, had a far greater impact on cognitive outcomes (mean cognitive composite score difference = -5.8, 95% CI = 1.2-10.5, p = 0.008).
conclusionBirthweight growth discordance of ≥20% confers an independent adverse effect on long-term neuro-development of the smaller twin. However, prior to 33 weeks' gestation, gestational age at birth adversely affects cognitive development to a greater extent than foetal growth discordance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.