Evidence map›Paper›PMID 26490493›Full record

Trial reportThe American journal of clinical nutrition2015

Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.

Bénédicte M J Merle, Rachel E Silver, Bernard Rosner, Johanna M Seddon

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00594672 (Age-Related Eye Disease Study), which is not on this map. Cited by 87 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 5 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00594672 active not recruitingnot on this map

Age-Related Eye Disease Study (AREDS) and AREDS2 Follow-Up

TypeobservationalSponsorNational Eye Institute (NEI)Ran2008Enrolled110ConditionsAge-Related Macular Degeneration, Cataract
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Bénédicte M J MerleOphthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA;ORCID http://orcid.org/0000-0003-1332-0954
Rachel E SilverOphthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA;
Bernard RosnerChanning Division of Network Medicine, Harvard Medical School, Harvard University, Boston, MA.
Johanna M SeddonOphthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA; jseddon@tuftsmedicalcenter.org.
Tufts Medical Center · USHarvard University · USTufts University · US

Funding

ETIOLOGIC STUDIES OF AGE-RELATED MACULAR DEGENERATIONR01EY011309 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SEDDON, JOHANNA M · 2003 to 2017
$9.3M
Use of Correlated Data Methods in OphthalmologyR01EY022445 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2013 to 2025
$4.6M
NEI NIH HHS R01 EY022445NEI NIH HHS R01-EY022445NEI NIH HHS R01-EY11309
6 · The paper itself

Abstract

backgroundAdherence to a Mediterranean-type diet is linked to a lower risk of mortality and chronic disease, but the association with the progression of age-related macular degeneration (AMD) and genetic susceptibility is unknown.

objectiveWe examined the association of adherence to the Mediterranean diet and genetic susceptibility with progression to advanced AMD.

designAmong 2525 subjects in the AREDS (Age-Related Eye Disease Study), 1028 eyes progressed to advanced AMD over 13 y. Baseline data for demographic and behavioral covariates were collected by using questionnaires. Dietary data were collected from food-frequency questionnaires. The alternate Mediterranean diet (aMeDi) score (range: 0-9) was constructed from individual intakes of vegetables, fruit, legumes, whole grains, nuts, fish, red and processed meats, alcohol, and the ratio of monounsaturated to saturated fats. Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2), complement factor B (CFB), complement component 3 (C3), collagen type VIII α 1 (COL8A1), and RAD51 paralog B (RAD51B)] were examined. Survival analysis was used to assess individual eyes for associations between incident AMD and aMeDi score, as well as interaction effects between aMeDi score and genetic variation on risk of AMD.

resultsA high aMeDi score (score of 6-9) was significantly associated with a reduced risk of progression to advanced AMD after adjustment for demographic, behavioral, ocular, and genetic covariates (HR: 0.74; 95% CI: 0.61, 0.91; P-trend = 0.007). The aMeDi score was significantly associated with a lower risk of incident advanced AMD among subjects carrying the CFH Y402H nonrisk (T) allele (P-trend = 0.0004, P-interaction = 0.04). The aMeDi score was not associated with AMD among subjects who were homozygous for the risk (C) allele.

conclusionHigher adherence to a Mediterranean diet was associated with reduced risk of progression to advanced AMD, which may be modified by genetic susceptibility. This trial was registered at clinicaltrials.gov as NCT00594672.

Indexed as

Diet, MediterraneanGenetic Predisposition to DiseasePolymorphism, Single NucleotideAgedAged, 80 and overAmino Acid SubstitutionBlindnessCohort StudiesComplement Factor HDisease ProgressionFemaleGenetic Association StudiesHumansIncidenceLongitudinal StudiesMacular DegenerationCFH protein, humanComplement Factor HAMD progressiongeneticsmacular degenerationMediterranean dietnutrition

Identifiers

PMID26490493
PMCPMC4625588
OpenAlexW1900193133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.