ArticleClinical cancer research : an official journal of the American Association for Cancer Research2016
Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer.Molecular cancer research : MCR · 2025Article
- Neighborhood Disadvantage and Prostate Tumor RNA Expression of Stress-Related Genes.JAMA network open · 2024Article
- The Crosstalk between Nerves and Cancer-A Poorly Understood Phenomenon and New Possibilities.Cancers · 2024Review
- The cancer-immune dialogue in the context of stress.Nature reviews. Immunology · 2024Review
- Psychosocial stressors and breast cancer gene expression in the Black Women's Health Study.Breast cancer research and treatment · 2024Article
- The influence of lifestyle changes (diet, exercise and stress reduction) on prostate cancer tumour biology and patient outcomes: A systematic review.BJUI compass · 2023Review
- Association of Neighborhood Deprivation With Prostate Cancer and Immune Markers in African American and European American Men.JAMA network open · 2023Article
- Review
- Neuroendocrine pathways and breast cancer progression: a pooled analysis of somatic mutations and gene expression from two large breast cancer cohorts.BMC cancer · 2022Article
- Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- An overview of cancer health disparities: new approaches and insights and why they matter.Carcinogenesis · 2021Review
- Cancer and Stress: Does It Make a Difference to the Patient When These Two Challenges Collide?Cancers · 2021Review
- The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors.Journal of cellular signaling · 2020Article
- Risk factors for incident prostate cancer in a cohort of world trade center responders.BMC psychiatry · 2019Article
- Socioenvironmental adversity and risk of prostate cancer in non-Hispanic black and white men.Cancer causes & control : CCC · 2019Article
- Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer.Molecular oncology · 2018Article
- Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway.Oncogene · 2018Article
- Analysis of Tumor Biology to Advance Cancer Health Disparity Research.The American journal of pathology · 2018Review
- Dysregulated stress-related signalling pathways associated with lethality of prostate cancer.Nature reviews. Urology · 2015Article
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Authors and funding
15 authors at 5 institutions in 4 countries.
Funding
Abstract
purposeRecent data suggest that neuroendocrine signaling may influence progression in some cancers. We aimed to determine whether genes within the five major stress-related signaling pathways are differentially expressed in tumor tissue when comparing prostate cancer patients with lethal and nonlethal disease. EXPERIMENTAL
designWe measured mRNA expression of 51 selected genes involved in predetermined stress-related signaling pathways (adrenergic, glucocorticoid, dopaminergic, serotoninergic, and muscarinic systems) in tumor tissue and normal prostate tissue collected from prostate cancer patients in the Physicians' Health Study (n = 150; n = 82 with normal) and the Health Professionals Follow-Up Study (n = 254; n = 120 with normal). We assessed differences in pathway expression in relation to prostate cancer lethality as the primary outcome and to biomarkers as secondary outcomes.
resultsDifferential mRNA expression of genes within the adrenergic (P = 0.001), glucocorticoid (P < 0.0001), serotoninergic (P = 0.0019), and muscarinic (P = 0.0045) pathways in tumor tissue was associated with the risk of lethality. The adrenergic pathway was also statistically significant (P = 0.001) when comparing against differential expression of genes not involved in the pathways. In adjacent normal prostate tissue, none of the pathways was clearly differentially expressed between lethal and nonlethal prostate cancer. The glucocorticoid and adrenergic pathways were associated with cell proliferation, while the glucocorticoid pathway was additionally associated with angiogenesis and perineural invasion.
conclusionsOur study suggests that stress-related signaling pathways, particularly the adrenergic and glucocorticoid, may be dysregulated in the tumors of men whose prostate cancer proves to be lethal, and motivates further investigation of these pathways in functional studies.
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