Trial reportAnnals of the rheumatic diseases1989
Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids.
Trial report in Annals of the rheumatic diseases, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The effect of Oenothera biennis (Evening primrose) oil on inflammatory diseases: a systematic review of clinical trials.BMC complementary medicine and therapies · 2024Pooled it
- The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis.Nutrients · 2022Pooled it
- Herbal therapy for treating rheumatoid arthritis.The Cochrane database of systematic reviews · 2011Pooled it
- Effects of evening primrose oil in rheumatoid arthritis.Annals of the rheumatic diseases · 1989Trial
- Effects of Dietary Linoleic Acid on Blood Lipid Profiles: A Systematic Review and Meta-Analysis of 40 Randomized Controlled Trials.Foods (Basel, Switzerland) · 2023Review
- Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations.Antioxidants (Basel, Switzerland) · 2021Review
- Herbs with anti-lipid effects and their interactions with statins as a chemical anti- hyperlipidemia group drugs: A systematic review.ARYA atherosclerosis · 2015Review
- Article
- Review
- The effect of borage oil consumption on the composition of individual phospholipids in human platelets.Lipids · 1992Article
- Essential fatty acids and inflammation.Annals of the rheumatic diseases · 1991Review
- Evening primrose oil and olive oil in treatment of rheumatoid arthritis.Clinical rheumatology · 1989Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.