ArticleChromosoma2016
Activity of telomerase and telomeric length in Apis mellifera.
Article in Chromosoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Ageing in Honeybees: Telomere Length Is Driven by Climate and Resource Availability Rather Than Urbanisation or Pollution.Global change biology · 2026Article
- Tissue-specific mitochondrial pathway remodeling linked to longevity in honeybee queens.PloS one · 2026Article
- Hypoxia extends lifespan but does not alter telomere length or oxidative stress in a solitary bee (Megachile rotundata).The Journal of experimental biology · 2025Article
- Extended longevity of termite kings and queens is accompanied by extranuclear localization of telomerase in somatic organs and caste-specific expression of its isoforms.Insect science · 2025Article
- Simple Sequence Repeats (SSRs) and Telomeric Analysis in Somatic Organs of Reproductive and Non-Reproductive Castes of TermiteBiology · 2025Article
- Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences.Insects · 2024Review
- Telomere length is longer following diapause in two solitary bee species.Scientific reports · 2024Article
- Telomeres and telomerase: active but complex players in life-history decisions.Biogerontology · 2024Review
- Telomeric DNA sequences in beetle taxa vary with species richness.Scientific reports · 2021Article
- Long-lived termite kings and queens activate telomerase in somatic organs.Proceedings. Biological sciences · 2021Article
- Seasonality in telomerase activity in relation to cell size, DNA replication, and nutrients in the fat body of Apis mellifera.Scientific reports · 2021Article
- Special Significance of Non-Frontiers in cell and developmental biology · 2020Review
- A hybrid de novo genome assembly of the honeybee, Apis mellifera, with chromosome-length scaffolds.BMC genomics · 2019Article
- Ectothermic telomeres: it's time they came in from the cold.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Experimental manipulation of telomere length: does it reveal a corner-stone role for telomerase in the natural variability of individual fitness?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomerase is an enzyme that adds repeats of DNA sequences to the ends of chromosomes, thereby preventing their shortening. Telomerase activity is associated with proliferative status of cells, organismal development, and aging. We report an analysis of telomerase activity and telomere length in the honeybee, Apis mellifera. Telomerase activity was found to be regulated in a development and caste-specific manner. During the development of somatic tissues of larval drones and workers, telomerase activity declined to 10 % of its level in embryos and remained low during pupal and adult stages but was upregulated in testes of late pupae, where it reached 70 % of the embryo level. Upregulation of telomerase activity was observed in the ovaries of late pupal queens, reaching 160 % of the level in embryos. Compared to workers and drones, queens displayed higher levels of telomerase activity. In the third larval instar of queens, telomerase activity reached the embryo level, and an enormous increase was observed in adult brains of queens, showing a 70-fold increase compared to a brain of an adult worker. Southern hybridization of terminal TTAGG fragments revealed a high variability of telomeric length between different individuals, although the same pattern of hybridization signals was observed in different tissues of each individual.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.