ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Seeking a blood pressure-independent measure of vascular properties.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Sex-specific hypothalamic PVN transcriptomic signatures of blood pressure autonomic regulation and neuroinflammation in hypertension.Biology of sex differences · 2026Article
- One Step Back from Bedside to the Bench-How Do Different Arterial Stiffness Parameters Behave in Relation to Peripheral Resistance?Diagnostics (Basel, Switzerland) · 2023Article
- Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness.American journal of physiology. Heart and circulatory physiology · 2019Article
- Evaluation of the calculation formulas of the cardio-ankle vascular index used in the Japanese apparatus.Vascular health and risk management · 2019Article
- Brachial-ankle pulse wave velocity, cardio-ankle vascular index, and prognosis.Vascular health and risk management · 2018Review
- New approach to arterial stiffness: BP-independent local carotid stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Ejection time: influence of hemodynamics and site of measurement in the arterial tree.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Observational
- Patient-specific blood pressure correction technique for arterial stiffness: evaluation in a cohort on anti-angiogenic medication.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- What is important for aging-induced arterial stiffening, autonomic dysfunction, vascular characteristics or both?Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Difference between ejection times measured at two different peripheral locations as a novel marker of vascular stiffness.PloS one · 2017Article
- The Effects of Hemodynamic Changes on Pulse Wave Velocity in Cardiothoracic Surgical Patients.BioMed research international · 2016Observational
- The Use of the Ambulatory Arterial Stiffness Index in Patients Suspected of Secondary Hypertension.Frontiers in cardiovascular medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulse wave velocity (PWV) and pulse pressure (PP) are blood pressure (BP)-dependent surrogates for vascular stiffness. Considering that there are no clinically useful markers for arterial stiffness that are BP-independent, our objective was to identify novel indices of arterial stiffness and compare them with previously described markers. PWV and PP were measured in young and old male Fisher rats and in young and old male spontaneously hypertensive rats (SHR) over a wide range of BPs. The BP dependence of these and several other indices of vascular stiffness were evaluated. An index incorporating PWV and PP was also constructed. Both PWV and PP increase in a non-linear manner with rising BP for both strains of animals (Fisher and SHRs). Age markedly changes the relationship between PWV or PP and BP. The previously described Ambulatory Arterial Stiffness Index (AASI) was able to differentiate between young and old vasculature, whereas the Cardio-Ankle Vascular Index (CAVI) did not reliably differentiate between the two. The novel Arterial Stiffness Index (ASI) differentiated stiffer from more compliant vasculature. Considering the limitations of the currently available indices of arterial stiffness, we propose a novel index of intrinsic arterial stiffness, the ASI, which is robust over a range of BPs and allows one to distinguish between compliant and stiff vasculature in both Fisher rats and SHRs. Further studies are necessary to validate this index in other settings.
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