ArticleEuropean radiology2016
Comparison of diagnostic performance for perinatal and paediatric post-mortem imaging: CT versus MRI.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Pooled it
- Novel imaging techniques to study postmortem human fetal anatomy: a systematic review on microfocus-CT and ultra-high-field MRI.European radiology · 2020Pooled it
- Joint European Society of Paediatric Radiology (ESPR) and International Society for Forensic Radiology and Imaging (ISFRI) guidelines: paediatric postmortem computed tomography imaging protocol.Pediatric radiology · 2019Guideline
- Dutch guideline for clinical foetal-neonatal and paediatric post-mortem radiology, including a review of literature.European journal of pediatrics · 2018Guideline
- Current Practices in Postmortem Investigation of Sudden Unexpected Death in Infancy.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- 7.0 Tesla MRI in fetal autopsy: a preliminary exploration of integrating image optimization with clinical practice in a multidisciplinary workflow.Quantitative imaging in medicine and surgery · 2026Article
- Diagnostic accuracy of unenhanced post-mortem CT and MRI compared to the non-forensic clinical autopsy: a prospective blinded study.Virchows Archiv : an international journal of pathology · 2026Article
- Virtual Post Mortem in Fetuses and Newborns for the Verification of Congenital Heart Malformations.Pediatric cardiology · 2026Article
- The Role of Plain Radiography in Assessing Aborted Foetal Musculoskeletal Anomalies in Everyday Practice.Journal of imaging · 2024Article
- Imaging of sudden unexpected death in infancy: a comprehensive nationwide French survey.Pediatric radiology · 2024Article
- Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography.BJR open · 2024Article
- Essence of postmortem computed tomography for in-hospital deaths: what clinical radiologists should know.Japanese journal of radiology · 2023Review
- Post-mortem perinatal imaging: what is the evidence?The British journal of radiology · 2023Review
- Ultra-high-field MRI of postmortem human fetal wrist joints: initial experience.European radiology experimental · 2023Article
- Usefulness of virtual autopsy in diagnosing pathologies in the paediatric population: A systematic review.SAGE open medicine · 2023Review
- 'Moving towards understanding', acceptability of investigations following stillbirth in sub-Saharan Africa: A grounded theory study.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- Postmortem computed tomography plus forensic autopsy for determining the cause of death in child fatalities.Pediatric radiology · 2022Article
- Review
- Comparison of postmortem whole-body contrast-enhanced microfocus computed tomography and high-field magnetic resonance imaging of human fetuses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
- Postmortem Micro-CT of Human Fetal Heart-A Systematic Literature Review.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo compare the diagnostic yield of whole-body post-mortem computed tomography (PMCT) imaging to post-mortem magnetic resonance (PMMR) imaging in a prospective study of fetuses and children.
methodsWe compared PMCT and PMMR to conventional autopsy as the gold standard for the detection of (a) major pathological abnormalities related to the cause of death and (b) all diagnostic findings in five different body organ systems.
resultsEighty two cases (53 fetuses and 29 children) underwent PMCT and PMMR prior to autopsy, at which 55 major abnormalities were identified. Significantly more PMCT than PMMR examinations were non-diagnostic (18/82 vs. 4/82; 21.9 % vs. 4.9 %, diff 17.1 % (95 % CI 6.7, 27.6; p < 0.05)). PMMR gave an accurate diagnosis in 24/55 (43.64 %; 95 % CI 31.37, 56.73 %) compared to 18/55 PMCT (32.73 %; 95 % CI 21.81, 45.90). PMCT was particularly poor in fetuses <24 weeks, with 28.6 % (8.1, 46.4 %) more non-diagnostic scans. Where both PMCT and PMMR were diagnostic, PMMR gave slightly higher diagnostic accuracy than PMCT (62.8 % vs. 59.4 %).
conclusionUnenhanced PMCT has limited value in detection of major pathology primarily because of poor-quality, non-diagnostic fetal images. On this basis, PMMR should be the modality of choice for non-invasive PM imaging in fetuses and children. KEY POINTS: • Overall 17.1 % more PMCT examinations than PMMR were non-diagnostic • 28.6 % more PMCT were non-diagnostic than PMMR in fetuses <24 weeks • PMMR detected almost a third more pathological abnormalities than PMCT • PMMR gave slightly higher diagnostic accuracy when both were diagnostic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.