ArticleScientific reports2015
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Role of Mitochondrial Calcium Dysregulation in Alzheimer's Disease Pathogenesis.Molecular neurobiology · 2025Review
- MICU proteins facilitate CaResearch square · 2025Article
- Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024Review
- Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy.Scientific reports · 2024Article
- Mitochondrial calcium uniporter channel gatekeeping in cardiovascular disease.Nature cardiovascular research · 2024Review
- MICU1 controls spatial membrane potential gradients and guides CaCommunications biology · 2022Article
- CaCells · 2022Review
- Mitochondrial calcium exchange in physiology and disease.Physiological reviews · 2022Review
- Mitochondrial CaInternational journal of molecular sciences · 2022Review
- Mitochondrial Calcium Uniporter Affects Neutrophil Bactericidal Activity during Staphylococcus aureus Infection.Infection and immunity · 2022Article
- Citrin mediated metabolic rewiring in response to altered basal subcellular CaCommunications biology · 2022Article
- Molecular nature and physiological role of the mitochondrial calcium uniporter channel.American journal of physiology. Cell physiology · 2021Review
- Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling.Applied sciences (Basel, Switzerland) · 2021Article
- Mitochondrial CaJournal of molecular and cellular cardiology · 2021Review
- Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift.IUCrJ · 2020Article
- The Mitochondrial CaFrontiers in physiology · 2020Review
- The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications.Advances in experimental medicine and biology · 2020Review
- Pathophysiology of Calcium Mediated Ventricular Arrhythmias and Novel Therapeutic Options with Focus on Gene Therapy.International journal of molecular sciences · 2019Review
- Article
- MICU1 controls cristae junction and spatially anchors mitochondrial CaNature communications · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
Mitochondrial Ca(2+) uptake is a vital process that controls distinct cell and organelle functions. Mitochondrial calcium uptake 1 (MICU1) was identified as key regulator of the mitochondrial Ca(2+) uniporter (MCU) that together with the essential MCU regulator (EMRE) forms the mitochondrial Ca(2+) channel. However, mechanisms by which MICU1 controls MCU/EMRE activity to tune mitochondrial Ca(2+) signals remain ambiguous. Here we established a live-cell FRET approach and demonstrate that elevations of cytosolic Ca(2+) rearranges MICU1 multimers with an EC50 of 4.4 μM, resulting in activation of mitochondrial Ca(2+) uptake. MICU1 rearrangement essentially requires the EF-hand motifs and strictly correlates with the shape of cytosolic Ca(2+) rises. We further show that rearrangements of MICU1 multimers were independent of matrix Ca(2+) concentration, mitochondrial membrane potential, and expression levels of MCU and EMRE. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells.
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