ArticleScientific reports2015
Zebrafish Models for Human Acute Organophosphorus Poisoning.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Exploratory evaluation of the systemic inflammatory response index and internally evaluated machine learning models for prognosis in acute pesticide poisoning.American journal of translational research · 2026Article
- Neuroprotective Effects of N-Acetylcysteine-Amide (AD4) in a Survival Mouse Model of Paraoxon Intoxication: Targeting Oxidative Stress, Neuroinflammation and Memory Impairments.Antioxidants (Basel, Switzerland) · 2025Article
- Assessing organophosphate insecticide retention in muscle tissues of juvenile common carp fish under acute toxicity tests.Toxicology reports · 2024Article
- New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project.Frontiers in toxicology · 2024Article
- Toxic effects and bioaccumulation of pinacolyl methylphosphonate acid in zebrafish following soman exposure to a water environment.RSC advances · 2023Article
- Temperature- and chemical-induced neurotoxicity in zebrafish.Frontiers in physiology · 2023Review
- Optimization of Application-Driven Development ofTissue engineering. Part B, Reviews · 2022Review
- Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues.iScience · 2022Article
- Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles.Frontiers in physiology · 2022Article
- Transcriptome-Based Identification of Genes Responding to the Organophosphate Pesticide Phosmet inGenes · 2021Article
- Article
- Article
- Developmental and Neurotoxicity of Acrylamide to Zebrafish.International journal of molecular sciences · 2021Article
- Article
- Discovery of treatment for nerve agents targeting a new metabolic pathway.Archives of toxicology · 2020Article
- Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists.Neurotoxicology · 2020Article
- Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish.Scientific reports · 2019Article
- Further characterization of the zebrafish model of acrylamide acute neurotoxicity: gait abnormalities and oxidative stress.Scientific reports · 2019Article
- Acrylamide acute neurotoxicity in adult zebrafish.Scientific reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning.
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