Evidence map›Paper›PMID 26489022›Full record

Trial reportPloS one2015

High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial.

Gordon Fisher, Andrew W Brown, Michelle M Bohan Brown, Amy Alcorn, Corey Noles, Leah Winwood, Holly Resuehr, Brandon George, Madeline M Jeansonne, David B Allison

5 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 103 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 15 pooled it
47.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01935323 nacompletednot on this map

High Intensity Interval Versus Continuous Moderate Intensity Training: Maximizing the Benefits of Exercise in Overweight Adolescents.

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2013 to 2014Enrolled30ConditionsMetabolism, Physical FitnessArmsHigh Intensity Interval Training, Moderate Intensity Training
NCT03753165 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of High Intensity Interval Exercise on Pain,Disability, and Autonomic Nervous System on Chronic Low Back Pain Patients

TypeinterventionalSponsorImam Abdulrahman Bin Faisal UniversityRan2018 to 2019Enrolled80ConditionsChronic Low Back PainArmsHigh intensity interval exercise
NCT03821818 unknown statusnot on this mapstarted 2018, after this paper: background citation

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

TypeobservationalSponsorGalveston Clinical Research FoundationRan2018 to 2019Enrolled20ConditionsObesityArmsFood Allergy Elimination + Willis Exercise
NCT05311280 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Effect of High Intensity Interval Exercise and Myofunctional Therapy on Obstructive Sleep Apnea: a Randomized Clinical Controlled Trial

TypeinterventionalSponsorTaoyuan General HospitalRan2022 to 2022Enrolled40ConditionsObstructive Sleep ApneaArmshigh intensity interval training plus myotherapy, home exercise plus myotherapy
NCT05700292 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of High-intensity Interval Training on Low-grade Systemic Inflammation in Obese Young Adults

TypeinterventionalSponsorUniversity of GuadalajaraRan2023 to 2023Enrolled32ConditionsObesityArmsHigh-intensity Interval Training, Moderate-intensity continuous training
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 15 syntheses or guidelines pooled it, 237 citations in OpenAlex.

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  9. Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  14. Short-Term (<8 wk) High-Intensity Interval Training in Diseased Cohorts.Medicine and science in sports and exercise · 2018
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gordon FisherDepartment of Human Studies, University of Alabama at Birmingham, Birmingham, AL, United States of America; Nutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Andrew W BrownNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Michelle M Bohan BrownDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States of America; Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, SC, United States of America.
Amy AlcornNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Corey NolesDepartment of Human Studies, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Leah WinwoodDepartment of Human Studies, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Holly ResuehrNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Brandon GeorgeNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Madeline M JeansonneNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
David B AllisonNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, United States of America; Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, United States of America; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States of America.
University of Alabama at Birmingham · USEnergetics (United States) · USClemson University · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1: BPCAUL1RR025777 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUAY-WOODFORD, LISA MARIE · 2008 to 2011
$22.3M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UAB Obesity Training ProgramT32DK062710 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill, Brooks C Wingo · 2004 to 2026
$5.5M
NCATS NIH HHS UL1 TR001417NCRR NIH HHS UL1 RR025777NCRR NIH HHS UL1RR025777NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30DK056336NIDDK NIH HHS P30 DK079626NIDDK NIH HHS T32 DK062710NIDDK NIH HHS T32DK062710
6 · The paper itself

Abstract

purposeTo compare the effects of six weeks of high intensity interval training (HIIT) vs continuous moderate intensity training (MIT) for improving body composition, insulin sensitivity (SI), blood pressure, blood lipids, and cardiovascular fitness in a cohort of sedentary overweight or obese young men. We hypothesized that HIIT would result in similar improvements in body composition, cardiovascular fitness, blood lipids, and SI as compared to the MIT group, despite requiring only one hour of activity per week compared to five hours per week for the MIT group.

methods28 sedentary overweight or obese men (age, 20 ± 1.5 years, body mass index 29.5 ± 3.3 kg/m2) participated in a six week exercise treatment. Participants were randomly assigned to HIIT or MIT and evaluated at baseline and post-training. DXA was used to assess body composition, graded treadmill exercise test to measure cardiovascular fitness, oral glucose tolerance to measure SI, nuclear magnetic resonance spectroscopy to assess lipoprotein particles, and automatic auscultation to measure blood pressure.

resultsA greater improvement in VO2peak was observed in MIT compared to HIIT (11.1% vs 2.83%, P = 0.0185) in the complete-case analysis. No differences were seen in the intention to treat analysis, and no other group differences were observed. Both exercise conditions were associated with temporal improvements in % body fat, total cholesterol, medium VLDL, medium HDL, triglycerides, SI, and VO2peak (P < 0.05).

conclusionParticipation in HIIT or MIT exercise training displayed: 1) improved SI, 2) reduced blood lipids, 3) decreased % body fat, and 4) improved cardiovascular fitness. While both exercise groups led to similar improvements for most cardiometabolic risk factors assessed, MIT led to a greater improvement in overall cardiovascular fitness. Overall, these observations suggest that a relatively short duration of either HIIT or MIT training may improve cardiometabolic risk factors in previously sedentary overweight or obese young men, with no clear advantage between these two specific regimes (Clinical Trial Registry number NCT01935323).

trial registrationClinicalTrials.gov NCT01935323.

Indexed as

Exercise TherapyAdipose TissueAdolescentAdultBlood PressureBody CompositionBody Mass IndexCardiovascular DiseasesHumansMaleMetabolic SyndromeObesityOverweightOxygen ConsumptionPhysical EnduranceRisk Factors

Identifiers

PMID26489022
PMCPMC4619258
OpenAlexW2167807982

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.