Evidence map›Paper›PMID 26488815›Full record

ReviewImmunity2015

Natural Killer Cell Memory.

Timothy E O'Sullivan, Joseph C Sun, Lewis L Lanier

Abstract readReview
In one paragraph

Review in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

212 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
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  8. Review
  9. Article
  10. Article
  11. Immune effects of lipids isolated fromFrontiers in nutrition · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. NK-derived exosomes in anti-tumor strategies.Medical oncology (Northwood, London, England) · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Timothy E O'SullivanImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Joseph C SunImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: sunj@mskcc.org.
Lewis L LanierDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: lewis.lanier@ucsf.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
The natural killer cell response against mouse cytomegalovirus infectionR01AI100874 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Joseph Chai-Yuen Sun · 2012 to 2026
$7.4M
NK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0M
NK and T Cell Costimulation by NKG2D/DAP10R37AI066897 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2015
$3.8M
Natural killer cell responses against viral infectionR00AI085034 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI SUN, JOSEPH CHAI-YUEN · 2010 to 2011
$498k
NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748NIAID NIH HHS AI066897NIAID NIH HHS AI068129NIAID NIH HHS AI085034NIAID NIH HHS AI100874NIAID NIH HHS R00 AI085034NIAID NIH HHS R01 AI068129NIAID NIH HHS R01 AI100874NIAID NIH HHS R37 AI066897NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.

Indexed as

Immunologic MemoryAdaptive ImmunityAdoptive TransferAnimalsAntigens, ViralApoptosisCD8-Positive T-LymphocytesCytokinesDermatitis, ContactHaptensHomeodomain ProteinsHomeostasisHumansInflammationKiller Cells, NaturalLymphocyte ActivationAntigens, ViralCytokinesHaptensHomeodomain ProteinsRAG-1 proteinReceptors, Natural Killer Cellcytomegalovirusimmunological memorynatural killer cells

Identifiers

PMID26488815
PMCPMC4621966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.