ArticleEndocrinology2016
Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3.
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Vitamin D supplementation and body fat mass: a systematic review and meta-analysis.European journal of clinical nutrition · 2018Pooled it
- Metabolomic basis for response to high dose vitamin D in critical illness.Clinical nutrition (Edinburgh, Scotland) · 2021Trial
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
- Adipose tissue protein profiling: modulation by vitamin D receptor.Frontiers in nutrition · 2026Article
- Testosterone Inhibits Lipid Accumulation in Porcine Preadipocytes by RegulatingAnimals : an open access journal from MDPI · 2024Article
- Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits.Genetics, selection, evolution : GSE · 2024Article
- Comparison of Serum Vitamin D Levels in Obese Subjects with and without Type 2 Diabetes Mellitus.Journal of inflammation research · 2024Article
- Review
- Vitamin D status and latitude predict brain lesions in adrenoleukodystrophy.Annals of the Child Neurology Society · 2023Article
- Integrated Transcriptome and Microbiota Reveal the Regulatory Effect of 25-Hydroxyvitamin D Supplementation in Antler Growth of Sika Deer.Animals : an open access journal from MDPI · 2022Article
- Mitochondrial potassium channels: A novel calcitriol target.Cellular & molecular biology letters · 2022Article
- The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities.Nutrients · 2021Review
- Probing the Scope and Mechanisms of Calcitriol Actions Using Genetically Modified Mouse Models.JBMR plus · 2021Article
- Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations.BMC medical genetics · 2020Article
- Vitamin D receptor promotes healthy microbial metabolites and microbiome.Scientific reports · 2020Article
- Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs.Journal of bone and mineral metabolism · 2019Article
- Coordination between the circadian clock and androgen signaling is required to sustain rhythmic expression ofThe Journal of biological chemistry · 2019Article
- Genetic and non-genetic effects of increased sun and vitamin D exposure: role in the observed healthy changes in cardiometabolic risk factors in Iranian children.Public health nutrition · 2018Article
- Article
- Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.Hepatology (Baltimore, Md.) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Fatty acids (FAs) are a major energy source in the body. White adipose tissue (WAT) is a primary site where FAs are stored as triacylglycerols. Brown adipose tissue also stores and recruits FAs as a carbon source for uncoupled β-oxidation during thermogenesis. The deletion of the vitamin D nuclear hormone receptor (VDR) gene in mice (VDRKO) results in a lean WAT phenotype with increased levels of expression of the brown adipose tissue marker Ucp1 in the WAT. However, the impact of vitamin D/VDR on FA composition in WAT has not been explored in detail. To address this question, we examined the FA composition of sc and visceral white adipose depots of VDRKO mice. We found that the levels of a subset of saturated and monounsaturated FAs of C18-C24 are specifically increased in the sc adipose depot in VDRKO mice. We revealed that a specific elongase enzyme (Elovl3), which has an important role in brown fat biology, is directly regulated by VDR and likely contributes to the altered FA composition in VDRKO mice. We also demonstrate that Elovl3 is regulated by vitamin D in vivo and tissue specifically in the sc WAT depot. We discovered that regulation of Elovl3 expression is mediated by ligand-dependent VDR occupancy of a negative-response element in the promoter proximal region of the Elovl3 gene. These data suggest that vitamin D/VDR tissue specifically modulates FA composition in sc WAT through direct regulation of Elovl3 expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.