ArticleBiophysical journal2015
Temperature Effect on Ionic Current and ssDNA Transport through Nanopores.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Coil-Globule versus Field-Driven Coil-Blob Transitions of PEG under Nanopore Confinement.ACS measurement science au · 2026Article
- Addressing the Challenges of Solid-State Nanopores: Strategies for Performance Enhancement.International journal of molecular sciences · 2026Review
- Editorial to the Special Issue "Theoretical and Computational Polymer Science: Physics, Chemistry, and Biology".Polymers · 2025Article
- Vectorial Discrimination of Small Molecules with a Macrocycle Adaptor-Protein Nanopore System and Nanocavity-Dependent, pH Gradient-Controlled Analyte Kinetics.Analytical chemistry · 2025Article
- Polymers in Physics, Chemistry and Biology: Behavior of Linear Polymers in Fractal Structures.Polymers · 2024Review
- Controlling DNA Fragments Translocation across Nanopores with the Synergic Use of Site-Directed Mutagenesis, pH-Dependent Charge Tuning, and Electroosmotic Flow.ACS applied materials & interfaces · 2024Article
- Review
- Translocation of Hydrophobic Polyelectrolytes under Electrical Field: Molecular Dynamics Study.Polymers · 2023Article
- Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges.International journal of molecular sciences · 2023Review
- Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore.Nature communications · 2022Article
- Biological nanopores for single-molecule sensing.iScience · 2022Review
- Translocation, Rejection and Trapping of Polyampholytes.Polymers · 2022Article
- Ionic heat dissipation in solid-state pores.Science advances · 2022Article
- Laser-based temperature control to study the roles of entropy and enthalpy in polymer-nanopore interactions.Science advances · 2021Article
- Article
- Conformational fluctuations of a DNA electrophoretically translocating through a nanopore under the action of a motor protein.The European physical journal. E, Soft matter · 2019Article
- A lithium-ion-active aerolysin nanopore for effectively trapping long single-stranded DNA.Chemical science · 2019Article
- Comparative biosensing of glycosaminoglycan hyaluronic acid oligo- and polysaccharides using aerolysin andThe European physical journal. E, Soft matter · 2018Article
- The aerolysin nanopore: from peptidomic to genomic applications.Nanoscale · 2018Review
- Translocation of polyampholytes and intrinsically disordered proteinsThe European physical journal. E, Soft matter · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
We have investigated the role of electrostatic interactions in the transport of nucleic acids and ions through nanopores. The passage of DNA through nanopores has so far been conjectured to involve a free-energy barrier for entry, followed by a downhill translocation where the driving voltage accelerates the polymer. We have tested the validity of this conjecture by using two toxins, α-hemolysin and aerolysin, which differ in their shape, size, and charge. The characteristic timescales in each toxin as a function of temperature show that the entry barrier is ∼15 kBT and the translocation barrier is ∼35 kBT, although the electrical force in the latter step is much stronger. Resolution of this fact, using a theoretical model, reveals that the attraction between DNA and the charges inside the barrel of the pore is the most dominant factor in determining the translocation speed and not merely the driving electrochemical potential gradient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.