ArticleBiophysical journal2015
Cytoskeletal Network Morphology Regulates Intracellular Transport Dynamics.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- The Evolution of Large Organism Size: Disparate Physiologies Share a Foundation at the Smallest Physical Scales.Life (Basel, Switzerland) · 2025Review
- Emerging role of long non‑coding RNAs in the Rho/ROCK signaling pathway in tumor metastasis (Review).International journal of molecular medicine · 2025Review
- Polarity sorting of actin filaments by motor-driven cargo transport.Biophysical journal · 2025Article
- Article
- FAST SOLVER FOR DIFFUSIVE TRANSPORT TIMES ON DYNAMIC INTRACELLULAR NETWORKS.SIAM journal on applied mathematics · 2024Article
- Review
- Optimizing microtubule arrangements for rapid cargo capture.Biophysical journal · 2021Article
- Diffusive search and trajectories on tubular networks: a propagator approach.The European physical journal. E, Soft matter · 2021Article
- Actin bundle architecture and mechanics regulate myosin II force generation.Biophysical journal · 2021Article
- Diffusion of kinesin motors on cargo can enhance binding and run lengths during intracellular transport.Molecular biology of the cell · 2021Article
- Hitching a Ride: Mechanics of Transport Initiation through Linker-Mediated Hitchhiking.Biophysical journal · 2020Article
- Molecular underpinnings of cytoskeletal cross-talk.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy.The British journal of radiology · 2020Article
- Microtubules Regulate Localization and Availability of Insulin Granules in Pancreatic Beta Cells.Biophysical journal · 2020Article
- Dynamic motions of molecular motors in the actin cytoskeleton.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Motility Control of Symbionts and Organelles by the Eukaryotic Cell: The Handling of the Motile Capacity of Individual Parts Forges a Collective Biological Identity.Frontiers in psychology · 2019Article
- Spatial Cytoskeleton Organization Supports Targeted Intracellular Transport.Biophysical journal · 2018Article
- Non-Markovian intracellular transport with sub-diffusion and run-length dependent detachment rate.PloS one · 2018Article
- System-wide organization of actin cytoskeleton determines organelle transport in hypocotyl plant cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Spatial pattern formation in microtubule post-translational modifications and the tight localization of motor-driven cargo.Journal of mathematical biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Intracellular transport is essential for maintaining proper cellular function in most eukaryotic cells, with perturbations in active transport resulting in several types of disease. Efficient delivery of critical cargos to specific locations is accomplished through a combination of passive diffusion and active transport by molecular motors that ballistically move along a network of cytoskeletal filaments. Although motor-based transport is known to be necessary to overcome cytoplasmic crowding and the limited range of diffusion within reasonable timescales, the topological features of the cytoskeletal network that regulate transport efficiency and robustness have not been established. Using a continuum diffusion model, we observed that the time required for cellular transport was minimized when the network was localized near the nucleus. In simulations that explicitly incorporated network spatial architectures, total filament mass was the primary driver of network transit times. However, filament traps that redirect cargo back to the nucleus caused large variations in network transport. Filament polarity was more important than filament orientation in reducing average transit times, and transport properties were optimized in networks with intermediate motor on and off rates. Our results provide important insights into the functional constraints on intracellular transport under which cells have evolved cytoskeletal structures, and have potential applications for enhancing reactions in biomimetic systems through rational transport network design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.