ArticlePLoS computational biology2015
Crawling and Gliding: A Computational Model for Shape-Driven Cell Migration.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 92 citations in OpenAlex.
- Confronting the challenge of cell segmentation in spatial transcriptomics.Nature methods · 2025Article
- Cell simulation as cell segmentation.Nature methods · 2025Article
- Cell populations simulated in silico within SimulCell accurately reproduce the behaviour of experimental cell cultures.NPJ systems biology and applications · 2025Article
- Improving 3D deep learning segmentation with biophysically motivated cell synthesis.Communications biology · 2025Article
- Cell Simulation as Cell Segmentation.bioRxiv : the preprint server for biology · 2024Article
- Fibronectin induces a transition from amoeboid to a fan morphology and modifies migration in Entamoeba histolytica.PLoS pathogens · 2024Article
- Collective Cell Radial Ordered Migration in Spatial Confinement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- How cells align to structured collagen fibrils: a hybrid cellular Potts and molecular dynamics model with dynamic mechanosensitive focal adhesions.Frontiers in cell and developmental biology · 2024Article
- Mesenchymal Migration on Adhesive-Nonadhesive Alternate Surfaces in Macrophages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Hybrid cellular Potts and bead-spring modeling of cells in fibrous extracellular matrix.Biophysical journal · 2023Article
- Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments.Biophysical journal · 2023Article
- An information theoretic approach to detecting spatially varying genes.Cell reports methods · 2023Article
- Flow rate resonance of actively deforming particles.Scientific reports · 2023Article
- Polarity and mixed-mode oscillations may underlie different patterns of cellular migration.Scientific reports · 2023Article
- Interpreting T-cell search "strategies" in the light of evolution under constraints.PLoS computational biology · 2023Article
- Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status.Frontiers in immunology · 2023Article
- Listeria motility increases the efficiency of epithelial invasion during intestinal infection.PLoS pathogens · 2022Article
- Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics.PLoS computational biology · 2022Article
- Mechanochemical subcellular-element model of crawling cells.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell migration is a complex process involving many intracellular and extracellular factors, with different cell types adopting sometimes strikingly different morphologies. Modeling realistically behaving cells in tissues is computationally challenging because it implies dealing with multiple levels of complexity. We extend the Cellular Potts Model with an actin-inspired feedback mechanism that allows small stochastic cell rufflings to expand to cell protrusions. This simple phenomenological model produces realistically crawling and deforming amoeboid cells, and gliding half-moon shaped keratocyte-like cells. Both cell types can migrate randomly or follow directional cues. They can squeeze in between other cells in densely populated environments or migrate collectively. The model is computationally light, which allows the study of large, dense and heterogeneous tissues containing cells with realistic shapes and migratory properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.