ArticlePloS one2015
The Low Noise Limit in Gene Expression.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Optimisation of gene expression noise for cellular persistence against lethal events.Journal of theoretical biology · 2025Article
- N-terminal tagging of RNA Polymerase II shapes transcriptomes more than C-terminal alterations.iScience · 2024Article
- A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks.Bulletin of mathematical biology · 2024Article
- 3Genome biology · 2021Article
- Mammalian gene expression variability is explained by underlying cell state.Molecular systems biology · 2020Article
- Cell Size-Based Decision-Making of a Viral Gene Circuit.Cell reports · 2018Article
- Homeostasis of protein and mRNA concentrations in growing cells.Nature communications · 2018Article
- The Pathway To Establishing HIV Latency Is Critical to How Latency Is Maintained and Reversed.Journal of virology · 2018Article
- Article
- Fine-tuning of noise in gene expression with nucleosome remodeling.APL bioengineering · 2018Article
- Computational Investigation of Environment-Noise Interaction in Single-Cell Organisms: The Merit of Expression Stochasticity Depends on the Quality of Environmental Fluctuations.Scientific reports · 2018Article
- Effects of growth rate and promoter activity on single-cell protein expression.Scientific reports · 2017Article
- Translation initiation events on structured eukaryotic mRNAs generate gene expression noise.Nucleic acids research · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Protein noise measurements are increasingly used to elucidate biophysical parameters. Unfortunately noise analyses are often at odds with directly measured parameters. Here we show that these inconsistencies arise from two problematic analytical choices: (i) the assumption that protein translation rate is invariant for different proteins of different abundances, which has inadvertently led to (ii) the assumption that a large constitutive extrinsic noise sets the low noise limit in gene expression. While growing evidence suggests that transcriptional bursting may set the low noise limit, variability in translational bursting has been largely ignored. We show that genome-wide systematic variation in translational efficiency can-and in the case of E. coli does-control the low noise limit in gene expression. Therefore constitutive extrinsic noise is small and only plays a role in the absence of a systematic variation in translational efficiency. These results show the existence of two distinct expression noise patterns: (1) a global noise floor uniformly imposed on all genes by expression bursting; and (2) high noise distributed to only a select group of genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.