Evidence map›Paper›PMID 26488283›Full record

ReviewAnnual review of microbiology2015

How Is Fe-S Cluster Formation Regulated?

Erin L Mettert, Patricia J Kiley

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
  2. Understanding Iron and Oxidative Stress Response inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Multi-Omics ofMicroorganisms · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Probing Transcriptional Crosstalk betweenInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Labile Iron Pool of IsolatedJournal of the American Chemical Society · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erin L MettertDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, email: elmettert@wisc.edu , pjkiley@wisc.edu.
Patricia J KileyDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, email: elmettert@wisc.edu , pjkiley@wisc.edu.
University of Wisconsin–Madison · US

Funding

The Regulation of Gene Expression by OxygenR01GM045844 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KILEY, PATRICIA J · 1991 to 2012
$4.4M
Bacterial anaerobic iron homeostasisR01GM115894 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KILEY, PATRICIA J · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM045844NIGMS NIH HHS R01 GM115894
6 · The paper itself

Abstract

Iron-sulfur (Fe-S) clusters are fundamental to numerous biological processes in most organisms, but these protein cofactors can be prone to damage by various oxidants (e.g., O2, reactive oxygen species, and reactive nitrogen species) and toxic levels of certain metals (e.g., cobalt and copper). Furthermore, their synthesis can also be directly influenced by the level of available iron in the environment. Consequently, the cellular need for Fe-S cluster biogenesis varies with fluctuating growth conditions. To accommodate changes in Fe-S demand, microorganisms employ diverse regulatory strategies to tailor Fe-S cluster biogenesis according to their surroundings. Here, we review the mechanisms that regulate Fe-S cluster formation in bacteria, primarily focusing on control of the Isc and Suf Fe-S cluster biogenesis systems in the model bacterium Escherichia coli.

Indexed as

Allosteric RegulationBacteriaCoenzymesEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialIronIron-Sulfur ProteinsSulfurCoenzymesEscherichia coli ProteinsIronIron-Sulfur ProteinsSulfurFe-Shomeostasisiron-sulfur clusterIsc pathwayregulationSuf pathway

Identifiers

PMID26488283
PMCPMC7487215
OpenAlexW2102837720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.