Evidence map›Paper›PMID 26488282›Full record

ReviewAnnual review of microbiology2015

Septins and Generation of Asymmetries in Fungal Cells.

Anum Khan, Molly McQuilken, Amy S Gladfelter

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Septin complexes: Ahead of the curve.Cytoskeleton (Hoboken, N.J.) · 2025
    Article
  4. Article
  5. Two Septin Complexes Mediate Actin Dynamics During Cell Wound Repair.bioRxiv : the preprint server for biology · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Candida albicans Hyphae: From Growth Initiation to Invasion.Journal of fungi (Basel, Switzerland) · 2018
    Review
  15. Article
  16. Review
  17. Article
  18. Septins Focus Cellular Growth for Host Infection by Pathogenic Fungi.Frontiers in cell and developmental biology · 2017
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anum KhanDepartment of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755; email: Amy.Gladfelter@Dartmouth.edu.
Molly McQuilkenDepartment of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755; email: Amy.Gladfelter@Dartmouth.edu.
Amy S GladfelterDepartment of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755; email: Amy.Gladfelter@Dartmouth.edu.
Dartmouth College · US

Funding

Molecular and Cellular Biology at DartmouthT32GM008704 · NIGMS · DARTMOUTH COLLEGE · PI COMPTON, DUANE A. · 1998 to 2018
$6.8M
Fluorescent single molecule orientation imaging in living cellsR01GM100160 · NIGMS · MARINE BIOLOGICAL LABORATORY · PI TANI, TOMOMI · 2012 to 2016
$1.6M
NIGMS NIH HHS GM100160NIGMS NIH HHS R01 GM100160NIGMS NIH HHS T32 GM008704
6 · The paper itself

Abstract

Polarized growth is critical for the development and maintenance of diverse organisms and tissues but particularly so in fungi, where nutrient uptake, communication, and reproduction all rely on cell asymmetries. To achieve polarized growth, fungi spatially organize both their cytosol and cortical membranes. Septins, a family of GTP-binding proteins, are key regulators of spatial compartmentalization in fungi and other eukaryotes. Septins form higher-order structures on fungal plasma membranes and are thought to contribute to the generation of cell asymmetries by acting as molecular scaffolds and forming diffusional barriers. Here we discuss the links between septins and polarized growth and consider molecular models for how septins contribute to cellular asymmetry in fungi.

Indexed as

Cell MembraneFungal ProteinsFungiSeptinsFungal ProteinsSeptinsasymmetrydiffusion barrierpolar growthscaffoldseptins

Identifiers

PMID26488282
PMCPMC5257338
OpenAlexW1911379139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.