Evidence map›Paper›PMID 26488274›Full record

ReviewAnnual review of microbiology2015

Bacterial Proteasomes.

Jordan B Jastrab, K Heran Darwin

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Observational
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Structural basis for the N-degron specificity of ClpS1 from Arabidopsis thaliana.Protein science : a publication of the Protein Society · 2021
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Emerging therapeutic targets for treatment of leishmaniasis.Expert opinion on therapeutic targets · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jordan B Jastrab
K Heran DarwinDepartment of Microbiology, New York University School of Medicine, New York, NY 10016; email: heran.darwin@med.nyu.edu.

Funding

MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2M
INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
PROTEASOME-DEPENDENT DEGRADATION IN MYCOBACTERIUM TUBERCULOSISR01AI088075 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katerina Heran Darwin · 2011 to 2026
$6.5M
Virulence Regulation by the Mycobacterium Tuberculosis ProteasomeR01HL092774 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DARWIN, KATERINA HERAN · 2007 to 2017
$4.0M
Characterization of a novel cofactor of the M. tuberculosis proteasomeF30AI110067 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JASTRAB, JORDAN B · 2014 to 2017
$111k
NHLBI NIH HHS HL92774NHLBI NIH HHS R01 HL092774NIAID NIH HHS AI088075NIAID NIH HHS F30 AI110067NIAID NIH HHS R01 AI088075NIAID NIH HHS T32 AI007180NIGMS NIH HHS T32 GM007308
6 · The paper itself

Abstract

Interest in bacterial proteasomes was sparked by the discovery that proteasomal degradation is required for the pathogenesis of Mycobacterium tuberculosis, one of the world's deadliest pathogens. Although bacterial proteasomes are structurally similar to their eukaryotic and archaeal homologs, there are key differences in their mechanisms of assembly, activation, and substrate targeting for degradation. In this article, we compare and contrast bacterial proteasomes with their archaeal and eukaryotic counterparts, and we discuss recent advances in our understanding of how bacterial proteasomes function to influence microbial physiology.

Indexed as

ArchaeaBacterial ProteinsEukaryotic CellsMycobacteriumMycobacterium tuberculosisProteasome Endopeptidase ComplexProteolysisBacterial ProteinsProteasome Endopeptidase ComplexMycobacteriumproteasomePuppupylationregulated proteolysis

Identifiers

PMID26488274
PMCPMC4702487

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.