Evidence map›Paper›PMID 26488086›Full record

ArticleJournal of the American Chemical Society2015

Spherical nanoparticle supported lipid bilayers for the structural study of membrane geometry-sensitive molecules.

Riqiang Fu, Richard L Gill, Edward Y Kim, Nicole E Briley, Erin R Tyndall, Jie Xu, Conggang Li, Kumaran S Ramamurthi, John M Flanagan, Fang Tian

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riqiang Fu *National High Magnetic Field Laboratory, Tallahassee, Florida 32310, United States.
Richard L Gill *Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033, United States.
Edward Y KimLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Nicole E BrileyDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033, United States.
Erin R TyndallDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033, United States.
Jie XuDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033, United States.
Conggang LiNational Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, P. R. China.
Kumaran S RamamurthiLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
John M FlanaganDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033, United States.
Fang TianDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033, United States.

Funding

Subcellular protein localization in B. subtilisZIABC011211 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RAMAMURTHI, KUMARAN · 2009 to 2025
$21.4M
Structural studies of tight junction proteinsR01GM094526 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FLANAGAN, JOHN M · 2013 to 2016
$1.8M
Molecular Insights into Membrane Curvature RecognitionR01GM105963 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI TIAN, FANG · 2014 to 2018
$1.6M
Intramural NIH HHSNIGMS NIH HHS R01 GM094526NIGMS NIH HHS R01GM094526NIGMS NIH HHS R01 GM105963NIGMS NIH HHS R01GM105963
6 · The paper itself

Abstract

Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

Indexed as

Bacterial ProteinsCell MembraneLipid BilayersMagnetic Resonance SpectroscopyMembrane ProteinsMolecular StructureNanoparticlesBacterial ProteinsLipid BilayersMembrane ProteinsspoVM protein, Bacillus subtilis

Identifiers

PMID26488086
PMCPMC4677685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.