ReviewDialogues in clinical neuroscience2015
Animal models for screening anxiolytic-like drugs: a perspective.
Review in Dialogues in clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Iron-induced Oxidative Stress and Anxiety-like Behavior in Wistar Rats Following Systemic Iron Administration.Biological trace element research · 2026Article
- Systemic Interplay of BDNF and Serotonin Pathways Defines Behavioral and Molecular Responses to Midbrain 5-HT7 Overexpression and Chronic Ethanol Consumption.Biomolecules · 2026Article
- Using a rich-lean transition procedure to evaluate putative antianxiety medications.The Journal of pharmacology and experimental therapeutics · 2025Article
- Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Analysis of Anxiety Disorders and Post-Traumatic Stress Disorders for Screening Anxiolytic Drugs and Linking Preclinical and Clinical Research.International journal of molecular sciences · 2025Review
- A New Insight into the Role of CART Peptide in Serotonergic Function and Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effects of sex and estrous cycle on action-outcome contingencies.Behavioural brain research · 2025Article
- Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway.Molecular brain · 2025Article
- Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age.Pharmacology, biochemistry, and behavior · 2025Article
- How can ethology inform the neuroscience of fear, aggression and dominance?Nature reviews. Neuroscience · 2024Review
- Neuritin Controls Axonal Branching in Serotonin Neurons: A Possible Mediator Involved in the Regulation of Depressive and Anxiety Behaviors via FGF Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ethnomedicinal Study and Evaluation of the Anxiolytic-like and Diuretic Effects of the OrchidPharmaceuticals (Basel, Switzerland) · 2024Article
- Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool.International journal of molecular sciences · 2024Review
- Deciphering Neuroprotective Effect ofCurrent drug targets · 2024Review
- Dose-Dependent Beneficial Effect of Ketone Supplement-Evoked Ketosis on Anxiety Level in Female WAG/Rij Rats: Sometimes Less Is More.Nutrients · 2023Article
- Anxiolytic-Pharmaceuticals (Basel, Switzerland) · 2023Article
- Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice.Current research in pharmacology and drug discovery · 2023Article
- Determination of steady-state transcriptome modifications associated with repeated homotypic stress in the rat rostral posterior hypothalamic region.Frontiers in neuroscience · 2023Article
- Drug Development for New Psychiatric Drug Therapies.Advances in neurobiology · 2023Article
- Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits.Advances in drug and alcohol research · 2023Review
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Contemporary biological psychiatry uses experimental animal models to increase our understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly targets specific pathways and molecular determinants within a single phenotypic domain. However, greater understanding of the mechanisms of action is possible through animal models. Primarily developed with rats, animal models in anxiety have been adapted with mixed success for mice, easy-to-use mammals with better genetic possibilities than rats. In this review, we focus on the three most common animal models of anxiety in mice used in the screening of anxiolytics. Both conditioned and unconditioned models are described, in order to represent all types of animal models of anxiety. Behavioral studies require careful attention to variable parameters linked to environment, handling, or paradigms; this is also discussed. Finally, we focus on the consequences of re-exposure to the apparatus. Test-retest procedures can provide new answers, but should be intensively studied in order to revalidate the entire paradigm as an animal model of anxiety.
Indexed as
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26487810PMC4610614What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.