ArticleDevelopment (Cambridge, England)2015
4D atlas of the mouse embryo for precise morphological staging.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
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- TT-PADM: A Time-Driven Transformer Diffusion Model for Robust Sparse-View and Limited-View Photoacoustic Tomography.BME frontiers · 2026Article
- Targeted downmodulation of OXTR and Cx43 in the myometrium by SERTIs as a novel tocolytic strategy.Uterine research · 2026Article
- Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex.Nature communications · 2025Article
- DeMBA: a developmental atlas for navigating the mouse brain in space and time.Nature communications · 2025Article
- Maternal Exposure to Carbamazepine at Environmentally Relevant Concentrations Causes Growth Delay in Mouse Embryos.ACS omega · 2025Article
- A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations.PLoS biology · 2025Article
- Quantifying the relationship between cell proliferation and morphology during development of the face.Development (Cambridge, England) · 2025Article
- Uncovering codon usage patterns during murine embryogenesis and tissue-specific developmental diseases.Frontiers in genetics · 2025Article
- Microphthalmia and disrupted retinal development due to abioRxiv : the preprint server for biology · 2024Article
- Microphthalmia and Disrupted Retinal Development Due to aEye and brain · 2024Article
- Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice.Communications biology · 2023Article
- Longitudinal in Utero Analysis of Engrailed-1 Knockout Mouse Embryonic Phenotypes Using High-Frequency Ultrasound.Ultrasound in medicine & biology · 2023Article
- Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential.The Biochemical journal · 2022Article
- Profiling development of abdominal organs in the pig.Scientific reports · 2022Article
- 4D reconstruction of murine developmental trajectories using spherical harmonics.Developmental cell · 2022Article
- Developmental neuroanatomy of the rosy bitterling Rhodeus ocellatus (Teleostei: Cypriniformes)-A microCT study.The Journal of comparative neurology · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
After more than a century of research, the mouse remains the gold-standard model system, for it recapitulates human development and disease and is quickly and highly tractable to genetic manipulations. Fundamental to the power and success of using a mouse model is the ability to stage embryonic mouse development accurately. Past staging systems were limited by the technologies of the day, such that only surface features, visible with a light microscope, could be recognized and used to define stages. With the advent of high-throughput 3D imaging tools that capture embryo morphology in microscopic detail, we now present the first 4D atlas staging system for mouse embryonic development using optical projection tomography and image registration methods. By tracking 3D trajectories of every anatomical point in the mouse embryo from E11.5 to E14.0, we established the first 4D atlas compiled from ex vivo 3D mouse embryo reference images. The resulting 4D atlas comprises 51 interpolated 3D images in this gestational range, resulting in a temporal resolution of 72 min. From this 4D atlas, any mouse embryo image can be subsequently compared and staged at the global, voxel and/or structural level. Assigning an embryonic stage to each point in anatomy allows for unprecedented quantitative analysis of developmental asynchrony among different anatomical structures in the same mouse embryo. This comprehensive developmental data set offers developmental biologists a new, powerful staging system that can identify and compare differences in developmental timing in wild-type embryos and shows promise for localizing deviations in mutant development.
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