ReviewDevelopment (Cambridge, England)2015
Heparan sulfate proteoglycans: a sugar code for vertebrate development?
Review in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 135 citations in OpenAlex.
- Regulated HSPG Signaling Directs Epicardial Behavior to Support Cardiac Formation.Circulation research · 2026Article
- Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish.Development (Cambridge, England) · 2026Article
- Article
- Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Serotonin neuromodulation directs optic nerve regeneration.Development (Cambridge, England) · 2025Article
- The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis.Cellular and molecular life sciences : CMLS · 2024Article
- The exostosin glycosyltransferase 1/STAT3 axis is a driver of breast cancer aggressiveness.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin.Frontiers in cell and developmental biology · 2024Article
- Characterization and ontogeny of a novel lymphoid follicle inducer cell during development of the bursa of Fabricius.Frontiers in immunology · 2024Article
- Heparanase-A single protein with multiple enzymatic and nonenzymatic functions.Proteoglycan research · 2023Review
- Teneurin trans-axonal signaling prunes topographically missorted axons.Cell reports · 2023Article
- Structure and evolution of neuronal wiring receptors and ligands.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning.EMBO reports · 2022Article
- Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications.Membranes · 2022Review
- Structure based innovative approach to analyze aptaprobe-GPC3 complexes in hepatocellular carcinoma.Journal of nanobiotechnology · 2022Article
- Recovery of Post-Stroke Spatial Memory and Thalamocortical Connectivity Following Novel Glycomimetic and rhBDNF Treatment.International journal of molecular sciences · 2022Article
- Gene-Interaction-Sensitive enrichment analysis in congenital heart disease.BioData mining · 2022Article
- Analyzing the Role of Heparan Sulfate Proteoglycans in Axon Guidance In Vivo in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Glypican 4 mediates Wnt transport between germ layers via signaling filopodia.The Journal of cell biology · 2021Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar chains have not yet been analyzed by genetics in vertebrates, recent studies have shown that HSPGs do indeed mediate a wide range of functions in early vertebrate development, for example during left-right patterning and in cardiovascular and neural development. Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.