Evidence map›Paper›PMID 26487703›Full record

ArticleChemical senses2016

Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES).

Shristi Rawal, Howard J Hoffman, Kathleen E Bainbridge, Tania B Huedo-Medina, Valerie B Duffy

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical senses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05216614 (Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia), which is not on this map. Cited by 92 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 6 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05216614 phase2withdrawnnot on this mapstarted 2021, after this paper: background citation

Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial)

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2022Enrolled0ConditionsCOVID-19, Olfactory Disorder, ParosmiaArmsFluvoxamine, Placebo
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 6 syntheses or guidelines pooled it, 184 citations in OpenAlex.

  1. Pooled it
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  4. Taste disorder's management: a systematic review.Clinical oral investigations · 2020
    Pooled it
  5. Interventions for managing taste disturbances.The Cochrane database of systematic reviews · 2017
    Pooled it
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shristi RawalDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT 06269, USA and.
Howard J HoffmanEpidemiology & Statistics Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Kathleen E BainbridgeEpidemiology & Statistics Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Tania B Huedo-MedinaDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT 06269, USA and.
Valerie B DuffyDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT 06269, USA and valerie.duffy@uconn.edu.
University of Connecticut · USNational Institute on Deafness and Other Communication Disorders · US

Funding

NIDCD NIH HHS Y1-DC-0013
6 · The paper itself

Abstract

Chemosensory problems challenge health through diminished ability to detect warning odors, consume a healthy diet, and maintain quality of life. We examined the prevalence and associated risk factors of self-reported chemosensory alterations in 3603 community-dwelling adults (aged 40+ years), from the nationally representative, US National Health and Nutrition Examination Survey (NHANES) 2011-2012. In this new NHANES component, technicians surveyed adults in the home about perceived smell and taste problems, distortions, and diminished abilities since age 25 (termed "alterations"), and chemosensory-related health risks and behaviors. The prevalence of self-reported smell alteration was 23%, including phantosmia at 6%; taste was 19%, including dysgeusia at 5%. Prevalence rates increased progressively with age, highest in those aged 80+ years (smell, 32%; taste, 27%). In multivariable logistic regression, controlling for sociodemographics, health behaviors, and chemosensory-related conditions, the strongest independent risk factor for smell alteration was sinonasal symptoms (odds ratio [OR] = 2.06; 95% confidence interval [CI]: 1.63-2.61), followed by heavy drinking, loss of consciousness from head injury, family income ≤110% poverty threshold, and xerostomia. For taste, the strongest risk factor was xerostomia (OR = 2.65; 95% CI: 1.97-3.56), followed by nose/facial injury, lower educational attainment, and fair/poor health. Self-reported chemosensory alterations are prevalent in US adults, supporting increased attention to decreasing their modifiable risks, managing safety/health consequences, and expanding chemosensory screening/testing and treatments.

Indexed as

Nutrition SurveysSelf ReportSmellTasteAdultAgedAged, 80 and overFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisRisk Factorsdry mouthdysgeusiahead injuryhealth statusphantosmia

Identifiers

PMID26487703
PMCPMC4715252
OpenAlexW2408511461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.