ArticleProceedings of the National Academy of Sciences of the United States of America2015
Cell-cycle progress in obligate predatory bacteria is dependent upon sequential sensing of prey recognition and prey quality cues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Predation in microbial communities: gradients of nutritive killing.Nature reviews. Microbiology · 2026Review
- Comparison of Predatory Phenotypes and Genotypes Between Bdellovibrio sp. BIS2 and Bacteriovorax sp. HI3 Isolated From the Same Freshwater Environment.Environmental microbiology · 2026Article
- Two-step localization driven by peptidoglycan hydrolase in interbacterial predation.The ISME journal · 2025Article
- Using AlphaFold-Multimer to study novel protein-protein interactions of predation essential hypothetical proteins inFrontiers in bioinformatics · 2025Article
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- Predatory Bacteria in the Treatment of Infectious Diseases and Beyond.Infectious disease reports · 2024Review
- Chromosome structure and DNA replication dynamics during the life cycle of the predatory bacterium Bdellovibrio bacteriovorus.FEMS microbiology reviews · 2023Review
- Predatory bacteria as potential biofilm control and eradication agents in the food industry.Food science and biotechnology · 2023Review
- Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography.Nature microbiology · 2023Article
- Advances in cellular and molecular predatory biology ofFrontiers in microbiology · 2023Review
- Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP-AMP to control predation in Bdellovibrio bacteriovorus.PLoS genetics · 2022Article
- An optimized workflow to measure bacterial predation in microplates.STAR protocols · 2022Article
- Chromosome choreography during the non-binary cell cycle of a predatory bacterium.Current biology : CB · 2021Article
- Insights into Bdellovibrio spp. mechanisms of action and potential applications.World journal of microbiology & biotechnology · 2021Review
- To hunt or to rest: prey depletion induces a novel starvation survival strategy in bacterial predators.The ISME journal · 2021Article
- Studies on Bd0934 and Bd3507, Two Secreted Nucleases fromJournal of bacteriology · 2020Article
- Insight into the Possible Use of the PredatorNutrients · 2020Review
- Potential Control of Potato Soft Rot Disease by the Obligate PredatorsApplied and environmental microbiology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Predators feed on prey to acquire the nutrients necessary to sustain their survival, growth, and replication. In Bdellovibrio bacteriovorus, an obligate predator of Gram-negative bacteria, cell growth and replication are tied to a shift from a motile, free-living phase of search and attack to a sessile, intracellular phase of growth and replication during which a single prey cell is consumed. Engagement and sustenance of growth are achieved through the sensing of two unidentified prey-derived cues. We developed a novel ex vivo cultivation system for B. bacteriovorus composed of prey ghost cells that are recognized and invaded by the predator. By manipulating their content, we demonstrated that an early cue is located in the prey envelope and a late cue is found within the prey soluble fraction. These spatially and temporally separated cues elicit discrete and combinatory regulatory effects on gene transcription. Together, they delimit a poorly characterized transitory phase between the attack phase and the growth phase, during which the bdelloplast (the invaded prey cell) is constructed. This transitory phase constitutes a checkpoint in which the late cue presumably acts as a determinant of the prey's nutritional value before the predator commits. These regulatory adaptations to a unique bacterial lifestyle have not been reported previously.
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