Evidence map›Paper›PMID 26487230›Full record

ArticleSurgical endoscopy2016

A pilot study of confocal laser endomicroscopy for diagnosing gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma.

Werner Dolak, Barbara Kiesewetter, Leonhard Müllauer, Marius Mayerhoefer, Marlene Troch, Michael Trauner, Michael Häfner, Markus Raderer, Andreas Püspök

Registry-linked trialAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01583699 (Confocal Laser Endomicroscopy as Diagnostic Tool for Gastrointestinal MALT-lymphoma), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01583699 nacompletednot on this map

Confocal Laser Endomicroscopy as Diagnostic Tool for Gastrointestinal MALT-lymphoma

TypeinterventionalSponsorMedical University of ViennaRan2012 to 2014Enrolled50ConditionsMALT-lymphomaArmsConfocal laser endomicroscopy, Confocal Laser Endomicroscope
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Werner DolakDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. werner.dolak@meduniwien.ac.at.
Barbara KiesewetterDivision of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Leonhard MüllauerClinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Marius MayerhoeferDepartment of Radiology and Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Marlene TrochDivision of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Michael TraunerDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Michael HäfnerDepartment of Internal Medicine, St. Elisabeth Hospital Vienna, Vienna, Austria.
Markus RadererDivision of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
Andreas PüspökDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma require lifelong endoscopic follow-up. This study aimed to establish and evaluate confocal laser endomicroscopy (CLE) criteria for gastrointestinal MALT lymphoma.

methodsThis prospective trial was conducted after IRB approval at the Medical University of Vienna. Twenty-four consecutive patients (14 males and 10 females, median age 65 years) referred for staging or follow-up of (former) gastrointestinal MALT lymphoma underwent endosonography (EUS) and CLE including white light endoscopy (WLE) and conventional biopsy sampling of the upper gastrointestinal tract. CLE criteria of the disease were based on the first five patients with histologically proven MALT lymphoma. All CLE datasets were reviewed separately by two CLE experts. The diagnostic modalities were compared using conventional histology as the gold standard.

resultsSixty-two percentages had a positive diagnosis of MALT lymphoma based on histology. The sensitivity was 80 % for EUS (0.51-0.95), 100 % for WLE (0.75-1) and 93 % for CLE (0.66-1); the specificity was 67 % for EUS (0.31-0.91), 23 % for WLE (0.04-0.60) and 100 % for CLE (0.63-1). The agreement with histology was moderate for EUS (kappa 0.47, p = 0.02), fair for WLE (kappa 0.26, p = 0.06) and almost perfect for CLE (kappa 0.91, p < 0.01). Expert evaluation identified all but one case of MALT lymphoma with excellent interobserver agreement (kappa 0.89, p < 0.01). In the case missed by CLE, MALT lymphoma involvement was restricted to deep tissue structures.

conclusionsDespite minor technical limitations, CLE is a promising alternative to conventional biopsy sampling in patients with gastrointestinal MALT lymphoma. CLINICALTRIALS. GOV NUMBER: NCT01583699.

Indexed as

AdultAgedAged, 80 and overBiopsyDouble-Blind MethodDuodenal NeoplasmsEndoscopyEndosonographyFemaleHumansLymphoma, B-Cell, Marginal ZoneMaleMicroscopy, ConfocalMiddle AgedNeoplasm StagingPilot ProjectsConfocal laser endomicroscopyEndosonographyMucosa-associated lymphoid tissue (MALT) lymphoma

Identifiers

PMID26487230
OpenAlexW2180094099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.