ArticleBMC neurology2015
Increased cortical activation upon painful stimulation in fibromyalgia syndrome.
Article in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 67 citations in OpenAlex.
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- Prefrontal cortex activation during daily movements and its association with clinical symptoms in knee osteoarthritis.Osteoarthritis and cartilage open · 2025Article
- Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness.Frontiers in neurology · 2025Review
- Characteristic of cerebral hemodynamics and functional connectivity in patients with neuropathic pain after spinal cord injury: an exploratory study.Frontiers in neuroscience · 2025Article
- Impact of sensory organization tasks on prefrontal cortex activity in older women: a comparative fNIRS study of osteoarthritis and healthy aging.Frontiers in aging neuroscience · 2025Article
- Visuotactile integration in individuals with fibromyalgia.Frontiers in human neuroscience · 2024Article
- Observational
- Review
- The mapping of cortical activation by near-infrared spectroscopy might be a biomarker related to the severity of fibromyalgia symptoms.Scientific reports · 2021Article
- Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.Nature reviews. Neurology · 2020Review
- A Cross-Sectional Study on Central Sensitization and Autonomic Changes in Fibromyalgia.Frontiers in neuroscience · 2020Article
- Cortical Binding Potential of Opioid Receptors in Patients With Fibromyalgia Syndrome and Reduced Systemic Interleukin-4 Levels - A Pilot Study.Frontiers in neuroscience · 2020Article
- Differential efficiency of transcutaneous electrical nerve stimulation in dominant versus nondominant hands in fibromyalgia: placebo-controlled functional near-infrared spectroscopy study.Neurophotonics · 2018Article
- Different mechanosensory stimulations of the lower back elicit specific changes in hemodynamics and oxygenation in cortical sensorimotor areas-A fNIRS study.Brain and behavior · 2016Article
- Cortical Sensorimotor Processing of Painful Pressure in Patients with Chronic Lower Back Pain-An Optical Neuroimaging Study using fNIRS.Frontiers in human neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain and associated symptoms. We investigated cerebral activation in FMS patients by functional near-infrared spectroscopy (fNIRS).
methodsTwo stimulation paradigms were applied: a) painful pressure stimulation at the dorsal forearm; b) verbal fluency test (VFT). We prospectively recruited 25 FMS patients, ten patients with unipolar major depression (MD) without pain, and 35 healthy controls. All patients underwent neurological examination and all subjects were investigated with questionnaires (pain, depression, FMS, empathy).
resultsFMS patients had lower pressure pain thresholds than patients with MD and controls (p < .001) and reported higher pain intensity (p < 0.001). Upon unilateral pressure pain stimulation fNIRS recordings revealed increased bilateral cortical activation in FMS patients compared to controls (p < 0.05). FMS patients also displayed a stronger contralateral activity over the dorsolateral prefrontal cortex in direct comparison to patients with MD (p < 0.05). While all three groups performed equally well in the VFT, a frontal deficit in cortical activation was only found in patients with depression (p < 0.05). Performance and cortical activation correlated negatively in FMS patients (p < 0.05) and positively in patients with MD (p < 0.05).
conclusionOur data give further evidence for altered central nervous processing in patients with FMS and the distinction between FMS and MD.
trial registrationISRCTN registry ID ISRCTN15015327 (24.09.2015).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.