ArticleScientific reports2015
Computational evidence that fast translation speed can increase the probability of cotranslational protein folding.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 22 citations in OpenAlex.
- Electrostatics of Prokaryotic Ribosome and Its Biological Implication.Biophysical journal · 2020Article
- Article
- Molecular simulations of cellular processes.Biophysical reviews · 2017Review
- Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins.Biophysical journal · 2017Article
- Does mRNA structure contain genetic information for regulating co-translational protein folding?Zoological research · 2017Review
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4 authors at 1 institution in 1 country.
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Abstract
Translation speed can affect the cotranslational folding of nascent peptide. Experimental observations have indicated that slowing down translation rates of codons can increase the probability of protein cotranslational folding. Recently, a kinetic modeling indicates that fast translation can also increase the probability of cotranslational protein folding by avoiding misfolded intermediates. We show that the villin headpiece subdomain HP35 is an ideal model to demonstrate this phenomenon. We studied cotranslational folding of HP35 with different fast translation speeds by all-atom molecular dynamics simulations and found that HP35 can fold along a well-defined pathway that passes the on-pathway intermediate but avoids the misfolded off-pathway intermediate in certain case. This greatly increases the probability of HP35 cotranslational folding and the approximate mean first passage time of folding into native state is about 1.67μs. Since we also considered the space-confined effect of the ribosomal exit tunnel on the cotranslational folding, our simulation results suggested alternative mechanism for the increasing of cotranslational folding probability by fast translation speed.
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