Evidence map›Paper›PMID 26486522›Full record

ArticleNeurogastroenterology and motility2016

Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats.

H Li, J Yin, Z Zhang, J H Winston, X-Z Shi, J D Z Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Burn-Induced Impairment of Ileal Muscle Contractility Is Associated with Increased Extracellular Matrix Components.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Article
  9. Review
  10. Article
  11. Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation.Evidence-based complementary and alternative medicine : eCAM · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

H LiDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
J YinDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Z ZhangDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
J H WinstonDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
X-Z ShiDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
J D Z ChenDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · USJohns Hopkins Medicine · USTongji Hospital · CN

Funding

EFFECTS AND MECHANISMS OF CHRONIC ELECTROACUPUNCTURE FOR EMESISR21CA149956 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHEN, JIANDE · 2010 to 2011
$361k
Synchronized Intestinal Electrical Stimulation for ObesityI01BX002010 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI CHEN, JIANDE · 2014 to 2017
–
BLRD VA I01 BX002010NCI NIH HHS CA149956NCI NIH HHS R21 CA149956
6 · The paper itself

Abstract

backgroundSevere burn injury has been demonstrated to delay gastric emptying. The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced gastric dysmotility in rats.

methodsPropranolol (β-adrenoceptor antagonist) was injected intraperitoneally after the rats underwent burn injury. All experiments were performed 6 h following burn/sham burn injury. AEA was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; cyclooxygenase (COX)-2 expressions in gastric tissue were measured using western blotting and real-time RT-PCR. KEY

results(i) Burn injury delayed gastric emptying (p = 0.006) and AEA increased gastric emptying by 49% (p = 0.045). (ii) Burn injury evoked a significant elevation in plasma noradrenaline, which was suppressed by AEA. (iii) Burn injury significantly increased protein and mRNA expressions of COX-2 in gastric fundus and antrum. AEA suppressed burn-induced increase in protein expressions, but not mRNA expressions of COX-2. CONCLUSIONS & INFERENCES: Burn injury delays gastric emptying by up-regulating COX-2 attributed to sympathetic overactivity. AEA improves burn-induced delay in gastric emptying, possibly mediated via the sympathetic-COX-2 pathway.

Indexed as

Acupuncture, EarAdrenergic beta-AntagonistsAnimalsBurnsCyclooxygenase 2ElectroacupunctureGastric EmptyingGastric FundusGastric MucosaGastroparesisPropranololPyloric AntrumRatsRNA, MessengerStomachUp-RegulationAdrenergic beta-AntagonistsCyclooxygenase 2PropranololPtgs2 protein, ratRNA, Messengerauricular electroacupunctureautonomic functionCOX-2gastric emptyingvagal nerve stimulation

Identifiers

PMID26486522
PMCPMC4688125
OpenAlexW2147219410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.