ArticleScientific reports2015
An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Reconstruction of the evolutionary landscape of biological processes involved in the early stages of the metastatic cascade.Genetics and molecular biology · 2026Article
- Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells.Molecular oncology · 2023Article
- New strategies for targeting kinase networks in cancer.The Journal of biological chemistry · 2021Review
- Article
- BRMS1: a multifunctional signaling molecule in metastasis.Cancer metastasis reviews · 2020Review
- Small Ones to Fight a Big Problem-Intervention of Cancer Metastasis by Small Molecules.Cancers · 2020Review
- Down Regulation of KAI1/CD82 in Lymph Node Positive and Advanced T-Stage Group in Breast Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Identification of differentially expressed genes and biological pathways in bladder cancer.Molecular medicine reports · 2018Article
- Article
- Commentary: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing ofFrontiers in cell and developmental biology · 2017Article
- GCGene: a gene resource for gastric cancer with literature evidence.Oncotarget · 2016Article
- CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases.Cell death & disease · 2016Article
- TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes.Nucleic acids research · 2016Article
- Meningiomas and Proteomics: Focus on New Potential Biomarkers and Molecular Pathways.Cancer genomics & proteomicsReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metastasis have identified many new susceptibility MS genes. However, the comprehensive illustration of diverse cellular processes regulated by metastasis suppressors during the metastasis cascade is lacking. Thus, the relationship between MS genes and cancer risk is still unclear. To unveil the cellular complexity of MS genes, we have constructed MSGene (http://MSGene.bioinfo-minzhao.org/), the first literature-based gene resource for exploring human MS genes. In total, we manually curated 194 experimentally verified MS genes and mapped to 1448 homologous genes from 17 model species. Follow-up functional analyses associated 194 human MS genes with epithelium/tissue morphogenesis and epithelia cell proliferation. In addition, pathway analysis highlights the prominent role of MS genes in activation of platelets and coagulation system in tumor metastatic cascade. Moreover, global mutation pattern of MS genes across multiple cancers may reveal common cancer metastasis mechanisms. All these results illustrate the importance of MSGene to our understanding on cell development and cancer metastasis.
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