ArticleEuropean journal of clinical nutrition2016
The levels of human milk microRNAs and their association with maternal weight characteristics.
Article in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- Non-Coding RNAs in Human Breast Milk: A Systematic Review.Frontiers in immunology · 2021Pooled it
- Maternal Obesity and MicroRNAs in Breast Milk: Implications for Infant Developmental Programming.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Characterization and biological health implications of microRNAs from human milk and infant formulas.NPJ science of food · 2025Review
- Milk-Derived Extracellular Vesicles and microRNAs: Potential Modulators of Intestinal Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming.Nutrients · 2025Review
- Human Breast Milk Exosomes: Affecting Factors, Their Possible Health Outcomes, and Future Directions in Dietetics.Nutrients · 2024Review
- Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding.Nutrients · 2024Review
- Review
- Recent insights into breast milk microRNA: their role as functional regulators.Frontiers in nutrition · 2024Review
- Micro RNA profiles in colostrum exosomes obtained from primiparous or multiparous dairy cows.Frontiers in veterinary science · 2024Article
- Associations between human milk EV-miRNAs and oligosaccharide concentrations in human milk.Frontiers in immunology · 2024Article
- Understanding the Immunological Quality of Breast Milk in Maternal Overweight and Obesity.Nutrients · 2023Review
- Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk: A Pilot Study.Exposure and health · 2023Article
- Human Breast Milk miRNAs: Their Diversity and Potential for Preventive Strategies in Nutritional Therapy.International journal of molecular sciences · 2023Review
- Review
- Review
- Regulation of adipogenesis by exosomal milk miRNA.Reviews in endocrine & metabolic disorders · 2023Review
- Influence of technical and maternal-infant factors on the measurement and expression of extracellular miRNA in human milk.Frontiers in immunology · 2023Article
- Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesSpecific microRNAs (miRNAs) that are known to have roles in various physiological and pathological processes in mammals are found in human breast milk, but the impact of maternal status on miRNA levels in milk is not fully understood. The objective of this study was to explore maternal and infant factors that can potentially influence the levels of let-7a (MIMAT0000062), miRNA-30B (MIMAT0000420) and miRNA-378 (MIMAT0000732) in human milk, all of which are known to participate in adipogenesis. SUBJECTS/
methodsColostrum from 86 mothers and mature milk from 33 mothers were collected. The miRNA levels in these samples were determined using real-time PCR. Correlations between the levels of these miRNAs and lactation duration, maternal weight/BMI before and late in the pregnancy, maternal age, gestational weeks and infant gender were analysed.
resultsThe levels of let-7a (2.58±0.67) and miRNA-378 (4.64±0.69) in colostrum were higher than those in mature milk (2.39±0.62, 3.62±0.77, P<0.01). Conversely, the level of miRNA-30B was higher in mature milk (4.92±0.57) than in colostrum (4.05±0.61, P<0.01). The levels of miRNA-30B, let-7a and miRNA-378 in colostrum were negatively correlated with maternal pre-pregnancy BMI (P<0.01), and, in mature milk, let-7a was negatively correlated with maternal weight late in the pregnancy (P<0.05). Moreover, miRNA-30B and miRNA-378 were higher in the colostrum received by girls than in that received by boys (P<0.01). This pattern held for miRNA-378 when controlling for maternal pre-pregnancy BMI.
conclusionsAdipogenesis miRNAs were expressed in both colostrum and mature milk and were related to maternal weight and infant gender. The miRNAs in human milk determined in this study provide a basis for future studies of their biological functions in infants.
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