ArticleScientific reports2015
Evaluation of selected interleukins in patients with different gastric neoplasms: a preliminary report.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- IL-6, IL-8, and IL-17A as predictive biomarkers for treatment response to PD-1 blockade immunochemotherapy in advanced gastric cancer.Archives of medical science : AMS · 2026Article
- Endoscopic findings in the upper gastrointestinal tract in patients with Crohn's disease are common, highly specific, and associated with chronic gastritis.Scientific reports · 2023Article
- Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature.Biomedicines · 2021Review
- High endothelial venule is a surrogate biomarker for T-cell inflamed tumor microenvironment and prognosis in gastric cancer.Journal for immunotherapy of cancer · 2021Article
- Association between interleukin gene polymorphisms and susceptibility to gastric cancer in the Qinghai population.The Journal of international medical research · 2021Article
- Lipoxins and Resolvins in Patients With Pancreatic Cancer: A Preliminary Report.Frontiers in oncology · 2021Article
- TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case-control study.Scientific reports · 2020Article
- Genomic analysis and clinical implications of immune cell infiltration in gastric cancer.Bioscience reports · 2020Article
- A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Amelioration of Alcohol Induced Gastric Ulcers Through the Administration ofFrontiers in microbiology · 2020Article
- Clinical significance of various growth factors in patients with different gastric neoplasms.American journal of translational research · 2020Article
- Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation.Scientific reports · 2019Article
- Hydroxyeicosatetraenoic acids in patients with pancreatic cancer: a preliminary report.American journal of cancer research · 2018Article
- Interleukins 17 and 23 in patients with gastric neoplasms.Scientific reports · 2016Article
- Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal interactions between cytokines may be an overlooked mechanism linking the development of different types of gastric neoplasms. In this study a comprehensive analysis of the systemic levels of interleukins (IL-1,IL-6, IL-8,IL-10 and IL-12) was performed in 75 patients with different gastric neoplasms (cancer, gastrointestinal stromal tumors, neuroendocrine neoplasms, lymphomas) and 40 healthy volunteers. Patients with gastric cancer (GC) have significantly higher IL-6 levels, and lower IL-8 and IL-10 concentrations, in comparison to controls and patients with other gastric neoplasms. Analogous results were observed in terms of IL-6/IL-8 and IL-6/IL-10 ratios, whose values were also higher in GC patients. In GC patients no associations were detected between the systemic levels/values of interleukins (ratios) and TNM staging. IL-6, IL-10, IL-6/IL-8 and IL-6/IL-10 ratios appeared to hold diagnostic potential in confirming/excluding the presence of GC. Their sensitivity/specificity in GC detection/exclusion was approximately 54-72%. In conclusion, disturbed systemic biochemical balance in multiple interleukins exists at the earliest stages of and appears to be specific to GC. The interleukin ratios proposed here seem to be more promising indicators of GC in humans than direct systemic levels of interleukins, and probably possess the potential to be applied as a supporting factor for techniques routinely used.
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